As the world progresses into the industrial age, a professor studying the "nature of pure matter" is spirited away by a would-be dictator and connived into building a super-bomb, as a young reporter and a girl rescued from the sea attempt to warn him of their mutual kidnapper's intentions to dominate the world with a new and more-deadly-yet weapon.

In the time of the Qing Dynasty, the Emperor Yongzheng created a secret army known as the Guillotines. It was the job of the Guillotines to protect the Emperor by killing anyone who posed a threat to him or his rule. After 348 successful missions to eliminate their target, the 349th assignment proves to be their last.