When a small town doctor buries his twin brother, a practitioner of the black arts, he believes him dead; but subsequent events force him to realize that his brother has, in fact, returned from the dead as a vampire and is seeking revenge on the doctor, who had killed him in self-defense.

This is a story about family relationships, set in the time before and during the American Civil War. Ethan Wilkins is a poor and honest man who ministers to the human soul, while his son Jason yearns to be a doctor, helping people in the earthly realm. It is a rich story about striving for excellence, the tension of father-son rebellion, and the love of a mother that can never die.

Osamu Ino is a great doctor who is beloved in his rural village. His knowledge and dedication make an equally strong impression on his reluctant medical intern, Keisuke Soma. But, Soma and the villagers reconsider their opinion when they learn about a shameful incident from Dr. Ino's past. Now the once-respected doctor must account for his past actions.

A small town doctor mistakenly ingests an experimental drug made from the blood of vampire bats which transforms the kindly medic into a bloodthirsty monster.

A rogue scientist near a small desert town arouses the suspicion of the town's doctor when his lab assistant is found dead from a case of acromegaly, which took only four days to develop. As the doctor investigates, aided by the scientist's new female assistant, they discover that something is devouring local cattle and humans in increasingly large quantities.

Civil War veteran Josiah Grey comes to a small town to be a gospel minister. In time, he has a family and many friends but also finds friction with a few of his parishioners.