Nisekoi follows high school students Raku Ichijo, the son of a leader in the yakuza faction Shuei-Gumi, and Chitoge Kirisaki, the daughter of a boss in a rival gang known as Beehive. They unexpectedly meet when Chitoge hops a wall and knees Raku in the face. After she runs off, Raku realizes he has lost his locket which was given to him by his childhood sweetheart with whom he made a secret promise. After discovering Chitoge is a new transfer student in his class, he forces her to help him look for the locket. During the search, they begin to dislike each other.[8]

Upon returning home, Raku learns that the Shuei-Gumi and Beehive gangs have agreed to settle their feud by pairing their leaders' children. Raku learns that his girlfriend-to-be is none other than Chitoge. For the next three years, they must pretend to be in a relationship to maintain peace between the gangs. This turns out to be quite a challenging task, not only because of their hatred for one another, but also because Raku has a crush on another schoolmate, Kosaki Onodera, whom he secretly wishes was the girl who bears the key to his locket. Various developments complicate the situation, including Chitoge's over-protective bodyguard, a female hitman, a girl who claims to be Raku's fiancée, and the existence of multiple keys.

Akebono City is a peaceful community overflowing with humanity. Since there was a Power Spot that released the magical power in the community, the people were distressed by the threat of the demon army Jamanga who are gathering Minus Energy (マイナスエネルギー Mainasu Enerugī) from the frightened masses for a sinister purpose. The secret organization S.H.O.T. was formed to protect the people of the community from the Jamanga, concealing their existence as ordinary members of the Akebono Police Station, which considers demons beyond their jurisdiction. Kenji Narukami, a student of the Narukami Dragon God Style (鳴神龍神流 Narukami Ryūjinryū) for fighting demons, arrives at Akebono to fight the demons, eventually getting his wish when he is transformed to RyuKenDo and faces off against Jamanga's forces together with his friends to restore peace in the community.

في هذه السلسلة التفاعليّة، ستتّخذ قراراتٍ مصيريّةً تساعد "بير غريلز" على البقاء والنجاح وإكمال المهامّ في أكثر مناطق الأرض قسوة.