The series focuses on an eccentric motley crew that is the Smith family and their three housemates: Father, husband, and breadwinner Stan Smith; his better half housewife, Francine Smith; their college-aged daughter, Hayley Smith; and their high-school-aged son, Steve Smith. Outside of the Smith family, there are three additional main characters, including Hayley's boyfriend turned husband, Jeff Fischer; the family's man-in-a-goldfish-body pet, Klaus; and most notably the family's zany alien, Roger, who is "full of masquerades, brazenness, and shocking antics."

The untold story of nothing less than the birth of rock ‘n’ roll. Guided by Sam Phillips, young musicians like Johnny Cash, Elvis Presley, Carl Perkins and Jerry Lee Lewis combined the styles of hillbilly country with the 1950s R&B sound created by artists like Muddy Waters, B.B. King, Fats Domino and Ike Turner, and changed the course of music forever.