Melvin Udall, a cranky, bigoted, obsessive-compulsive writer of romantic fiction, is rude to everyone he meets, including his gay neighbor, Simon. After Simon is hospitalized, Melvin finds his life turned upside down when he has to look after Simon's dog. In addition, Carol, the only waitress at the local diner who will tolerate him, must leave work to care for her sick son, making it impossible for Melvin to eat breakfast.
Though she can spin wild tales of passionate romance, novelist Joan Wilder has no life of her own. Then one day adventure comes her way in the form of a mysterious package. It turns out that the parcel is the ransom she'll need to free her abducted sister, so Joan flies to South America to hand it over. But she gets on the wrong bus and winds up hopelessly stranded in the jungle.
Joan Wilder is thrust back into a world of murder, chases, foreign intrigue... and love. This time out she's duped by a duplicitous Arab dignitary who brings her to the Middle East, ostensibly to write a book about his life. Of course, he's up to no good, and Joan is just another pawn in his wicked game. But Jack Colton and his sidekick Ralph show up to help our intrepid heroine save the day.
Gus is a fat cartoonist that recently won a battle against cancer, which explains his baldness. But he is also lonely. Therefore, his caring sister tries to set him up with suitable woman. But to do so, she must turn him into an irresistible man. When he falls in love with Emily, Gus takes the identity of a mysterious biker from New Zealand.
When Ethan arrives at the airport just in time to declare his undying love for his girlfriend, love appears to have conquered all. The scene, however, is really the ending of Ethan's novel, which his agent calls "unrealistic." Ethan soon meets a waitress, Jesse, and falls in love with her despite her growing devotion to Troy, a charming businessman. But the line between reality and fiction becomes increasingly blurred.
A aspiring novelist operates a tiny neighborhood bookstore. His wife is a talented painter. Their marriage is disintegrating, and they are about to sign their divorce papers. Meanwhile, the legendary Casanova and his lover Lavinia are characters trapped inside of a 17th-century children's book. The tragedy of the impending divorce triggers the release of Casanova and Lavinia from the confines of the children's pop-up book.
Romantic novelist Edith Hope so horrifies her friends that they banish her to the solitude of a Swiss hotel. She decides to work out her exile by observing her fellow guests.