Newly-paroled former US Army ranger Cameron Poe is headed back to his wife, but must fly home aboard a prison transport flight dubbed "Jailbird" taking the “worst of the worst” prisoners, a group described as “pure predators”, to a new super-prison. Poe faces impossible odds when the transport plane is skyjacked mid-flight by the most vicious criminals in the country led by the mastermind — genius serial killer Cyrus "The Virus" Grissom, and backed by black militant Diamond Dog and psychopath Billy Bedlam.

In the South Pacific island of Makatea, career-driven magazine editor Robin Monroe is on a week-long vacation getaway with her boyfriend, Frank Martin. An emergency work assignment in neighboring Tahiti requires Robin to hire the cantankerous pilot Quinn Harris who had flown them to Makatea on a small transport plane. While flying, a powerful storm forces Quinn to make an emergency landing on a nearby deserted island. The dissimilar pair avoid each other at first, until they're forced to team up to escape from the island -- and some pirates who want their heads.