Former police officer Darby Spencer and her mystery novelist mother Victoria Spencer have opposite personalities but still embark on the unlikeliest of ventures: becoming partners in a private detective agency. They are mistaken as sisters as they tackle puzzling cases in Alder Bluffs.

Charlie Grace is a Los Angeles private eye with a daughter named Jenny, works along with other cops, including his partner, Crawford, to solve different multiple mystery cases.

Two ill-fated men become a comic duo to investigate criminal cases involving a rare brain disease together.