Caroline og Sarah har ikke set hinanden i flere år. De blev uvenner da Sarah alligevel ikke ville donere sin nyre til Caroline. Da Carolines kæreste er hende utro beslutter hun sig for at forlade ham. Hun flytter ind hos Sarah der blevet et meget checket liv. Snart forsøger Caroline ligeledes at leve checket. Forholdet mellem Caroline og Sarah er stadig anstreng og efterhånden går det så skævt at Sarah smider Caroline ud. Søstrene indser dog hurtig at de stadig har en del glæde af hinanden.

Caroline is forced to leave her unfaithful boyfriend, and the only place she can crash is with her sister Sarah, with whom she does not get along. Sarah graciously offers Caroline a tiny room in her apartment and decides to help her find Mr. Right. Caroline isn't sure she's cut out for the dating game, but Sarah assures her there's nothing to it. Caroline is sent on a series of grueling and comic dates with everything from nimble pickup artists, to adventure sports freaks and a karaokesinging stockbroker. But in the end what the two sisters really find is themselves.