布瓦（Penpak Sirikul 饰）和丈夫阿威（Supachai Girdsuwan 饰）结婚多年，两人育有一女，生活十分幸福美满。然而，某一日，厄运降临到了她的头上，经医生确诊，布瓦患上了不治之症，时日无多。痛苦之中，布瓦决定不拖累家庭，同丈夫离婚，之后，她独自来到了度假村，想要在此了却余生。

She: Their Love Story is a tale of passionate female intimacy and the struggles of overcoming society's repressive demands to be true to themselves. Bua is a successful business woman with the "perfect life". Following a sudden cancer diagnosis she leaves her family behind to ease their pain and hide her destiny. Residing by the sea, she befriends June, an undemanding independent female photographer with a sensual energy and spirit. Meanwhile, Da has her reputation ruined when her "perfect" boyfriend emails out raunchy video clips of her. In order to escape the embarrassment she accepts a job to write a feature about the love life of lesbians in Bangkok. She convinces Bee, a charming tomboy, to be her research subject. As their lives cross, they all embark on a journey of emotional and sexual discovery: With Bua at the end of her life journey, she is granted one last chance to discover the profound meaning of passionate love.

Bua es una rica mujer de negocios que se ve obligada a esconder su fase terminal cancerígena a los ojos de su marido e hija, a los que acaba dejando. Inmersa en su trabajo conocerá a una joven fotógrafa que despertará su lado sexual más desconocido. Por otro lado, la columnista Da finalmente se decide a regañadientes a escribir sobre las mujeres homosexuales de Tailandia, pero sin saber que llegará más lejos de lo que imaginaba inicialmente.