同樣喜歡追求刺激的珍妮和拉娜是感情非常要好的死黨，火辣的珍妮對男人有著著魔般的狂熱，而拉娜雖為一名家庭主婦，但強悍的個性和高超的賭博技巧也多次讓她在牌桌上大賺一筆。一次因緣際會下，拉娜透過莊家拉比結識了幫派老大卡希姆，在見識過拉娜絕佳的牌技後，卡希姆決定派她參加一場獎金優渥的世紀賭局，但一向自信滿滿的拉娜卻在這次失了手，面對欠下龐大的賭金及心狠手辣的卡...

The true story of John Romulus Brinkley, a small-town Kansas doctor who discovers in 1917 that he can cure impotence by transplanting goat testicles into men. And that’s just the tipping point in this stranger-than-fiction tale. With the balls of a P.T. Barnum, the gonads of goats, and the wishful dreams of flaccid men, Brinkley amassed a fortune, was almost elected Governor of Kansas, invented junk mail and the infomercial, and built the world’s most powerful radio station. By the time all of the twists and turns of Brinkley’s story are revealed, Nuts! certainly earns its title.