A group of gay friends and lovers discuss love, sex, life and death as they exchange partners and try to dodge the bullet of AIDS in the drama Le traité du hasard. Patrick is a gay man whose circle of acquaintances provides the background for this story. They include Lou Rockfeller III, a flamboyant drag queen; Bruno (Bruno Anthony de Trigance), a former college professor who has since found success in the film industry; Daisy, a middle-aged author whose love life is a long litany of disasters; and Julien, a good-looking man who makes his living as a hustler. Julien was involved with Patrick at one time, and it turns out most of Patrick's friends have been with either him or Julien at one time or another -- which becomes a subject of grave concern when Julien develops a full-blown case of AIDS.

À Paris, entre 1995 et 1997, la chronique d’une petite bande d’homosexuels, genre «folles», confrontés à la séropositivité, chacun à sa manière. L’un d’eux va développer la maladie, mais sans y succomber, grâce à l’arrivée des trithérapies.