《法医秦明之亡命救赎》的故事背景从龙番市搬到清江市，讲述了身兼畅销书作家身份的法医秦明（邓飞 饰）来到清江市参加新书签售，偶遇清江首富张富国（袁祥仁 饰）的千金张静雅（希童 饰），受其委托调查张家母亲多年前的死因，却发现张富国书房被杀，同时牵扯出张家养子杨志远（闫艺泷）与张静雅、张霄鹏（黄皓达 饰）的恩怨情仇。张富国究竟被何人所杀，张家姐弟之间有藏着怎样不为人知的秘密……

Qin Ming came to Qingjiang City to participate in the sale of new bookmarks, and met Zhang Jingguo, the richest man in Zhangjiang, Qingjiang. When investigating the cause of Zhang’s mother’s death many years ago, he found that Zhang Fuguo’s study was killed, involving Zhang Zhiyang ’s son Yang Zhiyuan and his sister Zhang Jingya Resentment and resentment, Qin Ming found the cause of Zhang Fuguo's death after verifying the murders.