Over several years, we follow three households and their emotions in a barrio of Havana. Magalis is a nurse, rarely happy. An older man, Ignacio, professes his love for her; her father and her brother quarrel over her brother's sexual orientation; she thinks about leaving Cuba. Santo's wife Maria is expecting their first child. Tragedy strikes and Santo leaves, drowning sorrows in alcohol and crime while his son grows up in the care of an aunt wondering where dad is. Vivian and Chino are in love, passionate, but childless. The pressures of a society that demands grandchildren strain their relationship.

Magalis, Ignacio, Vivian, Miguelito y Santo son algunos de los personajes que pueblan "Barrio Cuba". Seres que buscan su pedazo de felicidad en La Habana. Seres que apuran la vida, que se rebelan contra un destino incierto y se empeñan una y otra vez en encontrar una salida. La realidad les golpea, pero ellos nunca pierden la esperanza de un futuro mejor, de recuperar un amor, de conseguirlo, de superarse...