Muthyala Subbaiah is an Indian film director. He has directed 50 Telugu films. Known for his films with heavy dose of human emotions, he is sometimes referred as Sentiment Subbaiah. Muthyala Subbaiah was born in Parlapalli, a village in Nellore district of Andhra Pradesh. His parents are Sankaraiah, Seshamma. He is the eldest of four children. He has two sisters and a brother. He was named after his grandfather Subbaiah. Their family lived on agriculture. He used to participate in stage shows since the age of 13 years. He did his B. Com from Vidavalur. He served as the secretary of Fine Arts Association in his college.

He was married to Parvathi when he was an assistant director. They have three children, two sons and a daughter.