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Diane Rehm (born Diane Aed; September 21,1936) is the host of Diane Rehm: On My Mind podcast, produced at WAMU, which is licensed to American University in Washington, D.C. She also hosts a monthly book club series, Diane Rehm Book Club, at WAMU. Rehm is also the former American public radio talk show host of The Diane Rehm Show, which was distributed nationally and internationally by National Public Radio. The show was also produced at WAMU.

Rehm had announced her plans to retire from hosting the show after the 2016 elections. The final program was recorded and distributed on December 23, 2016. Rehm announced she was going to host a weekly podcast, which she began doing in January 2017.

Rehm is also the co-producer, narrator, and interviewer of When My Time Comes, distributed by PBS stations across the country. Her book by the same name was published in 2020 by Knopf. The Washington Post describes Rehm as a leading voice in the right to die debate.