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Lee Patrick (November 22, 1901 – November 21, 1982) was an American actress whose career began in 1922 on the New York stage with her role in The Bunch and Judy which headlined Adele Astaire and featured Adele's brother Fred Astaire. Patrick continued to perform in dozens of roles on the stage for the next decade, frequently in musicals and comedies, but also in dramatic parts like her 1931 performance as Meg in Little Women. She began to branch out into films in 1929.

For half a century she created a credible body of cinematic work, her most memorable being in 1941 as Sam Spade's assistant Effie in The Maltese Falcon, and her reprise of the role in the George Segal 1975 comedy sequel The Black Bird. Her talents were showcased in comedies such as the 1942 Jack Benny film George Washington Slept Here and in 1958 as one of the foils of Rosalind Russell in Auntie Mame. Dramatic parts such as an asylum inmate in the 1948 The Snake Pit and as Pamela Tiffin's mother in the 1961 Summer and Smoke were another facet of her repertoire.

She made numerous guest roles in American television, but became a staple for that medium during the two-year run of Topper. As Henrietta Topper, her comedic timing played well against Leo G. Carroll as her husband, and against that of the two ghosts played by Robert Sterling and Anne Jeffreys. Patrick lent her voice to various animated characters of The Alvin Show in the early 1960s.

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Lee Salome Patrick (Nova York, 22 de novembre de 1901 - Laguna Beach, Califòrnia, 21 de novembre de 1982) va ser una actriu nord-americana la carrera de la qual va començar l'any 1922 als escenaris de Nova York amb el seu paper a The Bunch and Judy, que encapçalava Adele Astaire i comptava amb el germà d'Adele, Fred Astaire.