Все още замаян от смъртта на Стивън и в съзнание за предателството на Хелън, Ник Кътър трябва да се бори, за да върне съсредоточеността и желанието за работа на екипа си.

Сега към тях се присъединява невероятният полицай Дани Куин, египтоложката Сара Пейдж и новия лидер на силите за защита капитан Бекър.

Аномалиите продължават да се случват, още повече, че представляват реална заплаха за екипа и човечеството. Заплашителните създания от древния фолклор все по-често се превръщат в реалност, а с това става ясно, че старите митове и легенди са свързани преди всичко с мистични аномалии.

Египетски божества, дракони и други страшни създания се изпречват пред отряда на Кътър, който трябва да се справя с невъзможното, за да спаси живота на Земята.

Tým ARC se stále vzpamatovává ze Stephenovy smrti, a tak se k němu připojí několik nových členů, včetně nové velitelky bezpečnosti kapitánky Hilary Beckerové a energické egyptoložky Sarah Pageové. Mezitím se Helen Cutterová po objevení světa budoucnosti, kde je Země zamořena Predátory budoucnosti, vydává v přítomnosti na misi proti ARC, které viní z budoucí katastrofy, a podniká útok na ARC, při němž je Nick Cutter Helen zabit.

ARC se následně podaří od Helen získat záhadný artefakt z budoucnosti, což následně způsobí, že se vojenská spojka Christine Johnsonová zaměří na ARC a pokusí se nad ním převzít kontrolu a získat artefakt pro své vlastní účely. Po Cutterově smrti se k týmu ARC nakonec připojí bývalý policista a nový vedoucí týmu Danny Quinn a Jenny Lewisová se dozvídá o svém alternativním životě jako Claudia Brownová a nakonec ARC opouští.

As the ARC team still reel from Stephen's death, they are joined by several new team members, including new security leader Captain Hilary Becker, and sparky egyptologist Sarah Page. Meanwhile, after discovering a future world where the Earth is overrun with Future Predators, Helen Cutter sets out on a mission in the present against the ARC, whom she blames for the future catastrophe, and launches an attack on the ARC in which Nick Cutter is killed by Helen.

The ARC subsequently manage to obtain a mysterious artifact from the future from Helen, which in turn causes military liaison Christine Johnson to target the ARC and attempt to take control of it and get the Artifact for her own purposes. Following Cutter's death, the ARC team are ultimately joined by ex-cop and new team leader Danny Quinn, and Jenny Lewis learns of her alternate life as Claudia Brown and ultimately leaves the ARC. Meanwhile, Connor himself is forced to move out of Abby's flat and into Lester's (to the latter's chagrin and misery) when the troublesome Jack Maitland moves in with Abby.

As Johnson's mission to get the Artifact from the ARC continues, Helen returns and kills Johnson. When the ARC team learn that Helen intends to wipe out humanity's ancestors to stop them evolving to cause the future disaster, Danny, Connor and Abby are sent on a race after her through the Anomalies. Helen is killed before she can kill off enough of humanity's ancestors to have a temporal impact, but Abby, Connor and Danny are themselves left marooned in the past.

L’équipe de Nick Cutter est de retour ! Toujours sous le choc de la mort de Stephen et de l’ampleur de la trahison d’Helen, ils sont rejoints par de nouvelles recrues : le policier rebelle Danny Quinn, la sublime égyptologue Sarah Page, et le nouveau leader des forces de sécurité du CRA, le capitaine Becker. Des renforts bienvenus car de nouveaux monstres mortels font leur apparition et un danger d’une nouvelle envergure menace l’humanité entière…

失踪したカッター教授の妻ヘレンは、時空の扉を使った陰謀を企み、ARCを占拠、カッターを殺してしまう。悲しみにくれるチームは新たにダニーをリーダーとしてヘレンの陰謀を阻止しようとする...。