Set during the early Meiji era, Private Detective Shinjuro Yuki returns to Japan from abroad. He is trusted by Tokyo Metropolitan Police Department. Strange cases take place. Private Detective Shinjuro Yuki attempts to solve the cases. Meanwhile, Rie is the daughter of a powerful business man. She becomes attracted to Shinjuro Yuki.

明治初期，當世界逐漸轉向文明時，時代也發生了巨大的變化，不僅是人們的價值觀改變了，就連在變遷中所遺留下來的事件也相當不可思議。本劇將由福士蒼汰飾演的「結城新十郎」為視角，一一去深入、破解時代轉換之間的奇妙事件。

　　名作家坂口安吾作品「明治开化 安吾捕物帖」改编，以明治初期文明开化的东京为舞台，带出那个时代独有的推理模式。

　　故事讲述十九世纪末期，正值日本明治维新，人心不安、时局动荡，绅士侦探结城新十郎（福士苍汰）在东京神乐坂崭露头角，曾到海外的他得到警视厅的信赖，成为特命侦探。维新英雄胜海舟的前剑术弟子泉山虎之介一直喜欢在困难的案件中进行推理，却总是被结城耍弄。明治版的福尔摩斯，就此展开了一系列曲折奇妙的推理冒险。

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