Casey seems to have it all - she's in the best sorority, has the most popular boyfriend, and is in-line to become the next President of her sorority that is until her dorky brother, Rusty, comes to school and is determined to join a fraternity.

It's the first week of school and the first week of rush and neither is going particularly well for Rusty. On his very first night trying to become one with his pledge brothers, he fell asleep on the job. His "brothers" let him know they weren't too happy by leaving Rusty to dash off to class sans shoes, with blue feet and covered in mud. Rusty's professor was not amused.

Everyone is asked to suit up and pick sides as Kappa Tau and Omega Chi go head to head in floor hockey. But that’s not as easy as it looks. Casey is rooting for Evan and Omega Chi, naturally. So much so that she sets Cappie up for a fall. But did she do it to help her man or to get back at Rebecca? Because Casey and Rebecca may be “sisters” but they sure don’t play like a team. When Rebecca learns that Casey of “Casey and Evan” was formerly with Cappie, she uses the info to backstab Casey and get herself promoted to ZBZ’s head of Athletic Support. That’s when Casey shows what she’s made of—no one is going to beat her.

Cappie turns to Rusty for his brain power when the volcano for Kappa Tau's legendary Mt. Vesuvius party fails to erupt. Meanwhile, Casey and Evan are back on track as he introduces her to his powerful parents over dinner. But an unexpected appearance by Rebecca, a Senator's daughter, instantly bonds her to Evan's parents, leaving Casey to feel like an outsider with this blue-blood clan.

In Casey's bid to become president of Zeta Beta Zeta, she tries to win over her sorority pledges by throwing a slumber party that turns scary when the lights go out. Meanwhile, the same stormy night at Cyprus Rhodes University brings trouble for Cappie when he gets an unexpected visit from a beautiful and mysterious girl named Destiny.

As mid-term week approaches, the pressure is building for Rusty as he is determined to maintain his grades while keeping up his social life at the fraternity. Of course, Cappie has the answers for him but is it the right thing to do? Cappie not only presents Rusty with an appealing offer of help but when he is partnered with Casey on a school project, Casey is tempted once again by her past.

Couples are coming together. Couples are splitting apart. There’s Casey and Ashleigh—best friends and sorority sisters since freshman year, now they’re on the outs. Lack of support—Casey for Ashleigh—is the issue. But someone’s waiting in the wings to show Ashleigh she can be a friend, and that someone is Rebecca.

Allies become enemies when both Casey and Frannie are nominated for the title of Omega Chi Sweetheart. Who will prevail in this the ultimate cat fight? Meanwhile, as Rusty's relationship with Jen K. heats up, he longs for more private time with her but his judgmental roommate Dale is always around, making it difficult for the two lovebirds to spend time alone.

When a scandalous story in the college newspaper hits stands trashing the Greek system, the brothers and sisters of Omega Chia, Zeta Beta Zeta and even Kappa Tau are in a frenzy to figure out who the undercover culprit could be. Meanwhile, after navigating some troubled waters with her boyfriend, Ashleigh turns to Calvin for support and even goes so far as to hit on him, only to learn he has a secret.

Rusty and Casey return to CRU but must contend with the backlash from Jen K's story, and deal with the fallout from their relationships. Meanwhile, Cappie and Rebecca must make a choice about their relationship.

Hoping to sneak around Dean Bowman's probationary despotism, Casey tries to liven up the Zeta Betas by joining forces with Cappie and his Kappa Tau brothers to plan a Prohibition party with a Great Gatsby theme.

When the ZBZ girls express their desire to reunite with the Omega Chi's, Casey is put in a position of having to face her past relationship with Evan head on, causing her to come to grips with her feelings about him. Meanwhile, Rusty has a new crush and oddly enough it is Dale who helps him get a date with the girl. However, since Rusty has only had one relationship in the past, his eagerness to find someone new just might backfire.

The ZBZ girls throw a crazy competition among themselves as they each coach a different fraternity in a series of games. Casey coaches the Lambda Sigs and ends up developing a crush on one of the fraternity brothers. Meanwhile Rebecca tries to coach the Kappa Tau's and, at the sometime tests her relationship with Cappie.

Trouble is caused by Casey when she bends the sorority house rules for Ashleigh. Cappie tries to get rid of restrictions.

Meanwhile, Rusty finds himself attracted to Tina, the girl who wants to take down the Greek system.

Omega Chi and Kappa Tau each throw parties to celebrate the end of the campus restrictions.

Season 2 begins with the annual Greek Week competition. Despite their opposing houses, Calvin and Rusty strive to remain friends. Meanwhile, Casey has to decide what to do about Rebecca's actions over spring break, and Rebecca's continuous bad behavior doesn't do the situation any good.

Casey and Rusty organize a casino night in order to help a debt-plagued Ashleigh. Elsewhere, Evan struggles with accepting the fine print on his trust fund. Cappie's in need of new car. And, Rebecca wants more from a relationship but she's not sure if she'll get it from Cappie.

Rusty is looking into the list of Kappa Tau actives and this makes him very nervous about one member's true identity being uncovered. Also, Casey seems to like Max, Rusty's R.A. And Ashleigh accepts to accompany Calvin and Michael to a gay bar as Michael says Calvin doesn't have enough gay friends.

The ZBZ women attend their national sorority convention; a party for the engineering department gets out of control; Evan takes advantage of Frannie's absence.

Frannie and Casey sling mud at each other as the sorority presidential election approaches; Calvin faces the consequences after he cheats on Michael.

Casey faces a hard decision when she learns that Max is planning to go to Cal Tech for grad school and she is offered an internship. She turns to Lauren Conrad (who appears in a dream sequence) for advice. Also, the pledges are put through Hell Week and Rusty is driven to face the challenge no matter what he is forced to do.

Now a sophomore, Rusty gets to participate in Rush Week for the first time and he is determined to land Andy as a pledge for Kappa Tau, but Calvin feels the pressure from Evan to get Andy to pledge Omega Chi. Who will prevail in the battle for the big man on campus? Ashleigh and Casey start to doubt Rebecca's "mole" abilities and begin to question whether she's actually a double-agent for Frannie's new sorority when the ZBZ girls’ rush week “Project Runway” fashion skit is successfully sabotaged by Frannie.

The KTs race to return a stash of stolen campus goods, hoping not to get caught by security. Elsewhere, Casey sneaks Max into a faculty party so he can meet a visiting professor that needs an intern, and Ashleigh considers taking her relationship with Fisher public.

Rusty attempts to solve a mystery involving a secret service he ran across on campus in hopes of impressing Cappie. Meanwhile, some of Frannie's defectors from ZBZ house have asked to return, and Rebecca seeks dating advice from Calvin as she readies to go out with Robin.

Rusty and Ashleigh try hard to win the float competition, while Casey and Cappie try avoid each other as Homecoming Week heats up. Elsewhere, Evan gets word that he may lose his trust fund, and Ashleigh uncovers one of Fisher's secrets.

After she falls into a manhole risking her life, coupled with the Kappa Tau's throwing an "End of the World" party, Casey is sent into an emotional tailspin, questioning her relationship with Max and her lingering feelings for Cappie. Meanwhile, Ashleigh faces her own punishment with Pan Hellenic after a complaint is lodged by Frannie for the Homecoming Float sabotage. Ashleigh turns to Casey to help fight the charge, but when Casey gets caught up in her own personal drama, she leaves Ashleigh to face Frannie alone. And with Dale having trouble keeping his cougar girlfriend's sexual advances at bay and Calvin trying his best to resist hooking up with his new hot roommate, Grant. Dale convinces Calvin to go in on a "purity pledge" partnership so they can help each resist their most recent temptations.

It's time for the annual all-Greek "Undie Run", and the Pan-Hellenic board voted strongly against it. In an effort to change the vote, Casey uses her political savvy to enlist IFC president, Evan, to stage a petition signing. Meanwhile, it's nearing the end of the Greek-wide game of Gotcha!, and only Rusty and Jordan are left, which puts a damper in their effort to spend alone time together. Additionally, Evan finds out about Calvin and Grant's relationship and helps them keep it a secret from the rest of Omega Chi.

Shocked to learn that ZBZ has slipped in the ranks down to fourth, Casey is determined to bring ZBZ back to the number one spot by motivating their pledge class to take action, believing that, if they create a cool photo shoot for the Lamda Sig calendar, it could improve their house’s ranking. However new pldge Abby convinces the other pledges to boycott the shoot so, in order to make nice with the ZBZ pledges, Ashley and Casey get them all makeovers. Meanwhile, dissatisfied with her college experience, Jordan wonders how to make her time at CRU more fulfilling and, in an effort to prove his love and commitment for Jordan Rusty decides to lavaliere her. When Rusty divulges his plans to his KT brothers, they warn him of the Kappa Tau curse that occurs when a brother lavalieres his girlfriend. Elsewhere, Cappie helps Evan find a part time job to help his financial situation, but when he meets one of Evan’s new and very attractive co-workers, Lana, he decides to get a job too.

In Casey and Ashleigh’s continuing struggle to bring ZBZ back to the top, Ashleigh decides a four-way mixer is the best way to gain their popularity back. Will her party save ZBZ from the fourth spot, or will she put them in even more debt?

Everyone is packing their bags and heading home for Thanksgiving, but Casey and Rusty find themselves stranded at CRU when their parents leave them behind for Maui. Will Thanksgiving at CRU beat going home for the holidays? A surprise at the end will leave you speechless and wanting more.

Cappie and Casey go public, and Omega Chi and Kappa Tau get serious about pranking. Things heat up when Song Fest pits ZBZ against Gamma Psi. Rusty and Dale take their rivalry out of the lab.

The Cyprus Rhodes students are preparing for the "Help Us Rebuild Our Castle Fairytale Ball" for the Gamma Psi's - some out of guilt - by picking out their best prince and princess attire.

It's the All-Greek baseball game and alliances are tested on and off the field. With the hope of winning more blue ribbon points, the ZBZs partner with the Omega Chi's, throwing off Cappie and Casey's love game by pitting them against each other. Watch the Greeks take to the field.

Casey and Cappie get a surprise visit from Cappie's parents, April and Tobias who proceed to invite the couple to join them on a camping trip. While at first reluctant, Casey decides to go, in hopes that they may be able to encourage Cappie to choose a major and graduate with her. But she quickly learns that his parents are free-loving hippies who think Cappie should just relax and continue to enjoy his college experience.

The KTs and OXs are preparing for the Gods of Golf Tournament, the winner of which will be named the top fraternity on campus. Meanwhile, the ZBZs are disappointed to learn that the annual Greek Week has been canceled. Casey talks to Katherine, who agrees to bring back the Greek Goddesses Pageant, under the condition that the competition focus more on strength of character and less on looks, of course. Which houses will end the year on top?

The students of CRU are on Spring Break in Myrtle Beach, which means the year is winding down and the seniors have big decisions looming over their heads. As Ashleigh contemplates her job options, Casey is on edge waiting to see where she'll be accepted to law school. While Cappie is busy planning a romantic surprise for Casey's birthday, she worries that not making it into CRU Law could mean the demise of their relationship. Will Cappie and Casey survive Spring Break intact?

The season opens with Casey, Evan, & Ashleigh’s graduation day. Casey and Cappie haven’t spoken since Spring Break and are anticipating saying their final goodbyes to each other, which does not go as smoothly as expected. We then skip to the end of summer and Casey packing up to move to Washington DC for law school. Through some prompting from Evan, Casey learns that the reason she did not get into CRU law school was a result of a bad recommendation from Joel (Sam Page). After Casey confronts Sam, he reconsiders and has his letter rescinded. Casey is accepted into CRU law and decides to stay after all. Ashleigh has moved to New York for an internship that is not exactly what she was hoping for. Evan is attending CRU law school with Casey.

The KT’s decide since they lost several members of their frat last year, it’s time to actually try to recruit pledges. The KTs set up a booth during rush on campus to help with recruiting. Tegan (Charisma Carpenter) shows up to help the ZBZs maintain their newly regained best house on campus title. Tegan and Rebecca argue on how rushing should go and Casey comes to Rebecca’s rescue with a plan to have Dana (Martha MacIsaac) keep Tegan distracted. The ZBZs entertain a potential new pledge Heather, who is Heath’s sister. Dale also entertains the idea of rushing this semester

Beaver goes to class to find he got an F on his paper because it‘s plagiarized. He‘s needs to write a decent, original paper by the next morning or the F stays on his record. Casey talks with Katherine in hopes of forming a study group with her, but Katherine says she doesn‘t like study groups. Beaver meets Katherine, and is instantly smitten. Rusty and Dana are working on a science project together, and Ashleigh joins in to help make their slideshow more presentable. Dana requests to be called a co-inventor on the credits page, but when Rusty finds out, his anger ruins the presentation. The committee likes the invention, but pulls Rusty from the project and gives it to a professional team. Rebecca invites Cappie to the pledge party so she can make Evan jealous. Casey and Beaver team up in search of case summaries for Casey. Beaver accidentally invites Katherine along as they search for notes, much to Casey‘s dismay.

Lasker Parkes (Jonathan Silverman), Peter‘s dad, comes to visit Kappa Tau, and Cappie feels pressure to impress the him. Cappie plans an Everest party for Homecoming, complete with ice luges throughout the house. Lasker wants to know who is Peter‘s big brother in the. Rusty wants to be Peter‘s big brother, but Peter wants Cappie. Meanwhile, Casey tries to convince Ashleigh to find a job and move out, but Ashleigh keeps dragging her feet. Casey and Evan go to an alumni dinner because their law professor will be there. Casey gets into a fight with Ashleigh. To impress Peter, Rusty plans to steal the A&M goat mascot at night, but while they‘re in the process, Dale and some Omega Chi members interrupt with the same plan.

Rusty is planning Calvin‘s 21st birthday party at his apartment. Casey and Ashleigh have not been speaking and are afraid to run into each other at the party. A really bad snowstorm hits Cyprus Rhodes shutting down all roads. Since Heath is not able to make it back with the alcohol, the gang of eight decides to walk to Dobbler‘s. Inside Dobbler‘s, the group decides to play the game "Kiss & Tell" where secrets and feelings are revealed.

In the series finale, the Kappa Taus try to stop the demolition of their house. Meanwhile, Cappie and Casey come to a realization about their on-again, off-again romance; and Cappie and Evan determine whether their friendship is meant to last.