To keep up with his brother Benoit, Jimmy tries to convince his parents that he will introduce a new girlfriend at the gallery opening. Instead, it is Katrine who accompanies Jimmy to the opening, where she is bewildered to discover that her photo is featured among the works of art.

The friends go on a road trip to Vermont in the hopes of getting Bynucin, a medicine illegal in Canada, but which could help Katrine live longer without the need for a lung transplant.

Jimmy supports Katrine, who is just about to have her lung transplant. However, Katrine's parents are beginning to get tired of the nonsense between friends.

After learning about what has happened to Katrine, Jimmy wants to leave work to be with her. However, his boss is fed up with the constant distractions. Katrine tells the others about her new plan, but they are not sure about the idea.

Facing the greatest challenge of her life, Cindy looks for comfort. She comes to realize that, despite their best intentions, people sometimes only make things worse. Her friends, however, are always there to help distract her.

While everything is going from bad to worse, the foursome reunites in a bowling alley to spend time together and take their minds off of their problems. However, Katrine is hiding something from her friends.

Katrine's friends and family have never been as worried about her as they are now. Jimmy remembers how his friendship with her began. When Katrine's fate is finally sealed, the foursome is thrust onto a new path which none of them had expected.