The Mr. Men Show, a North American remake of the British series, Mr. Men and Little Miss, is virtually identical to the original British version, apart from the live-action skits, actors and actresses, theme song, and credits. Its original air was in Canada. Its air in the USA started in the fall of 1997, syndicated by the Summit Media Group. In the American version, there were live action characters including The News Lady, The Game Show Guy,a carpenter with his assistant, and a mad scientist with her assistant, among others.

The re-voiced animated segments from this show later appeared on their own on Cartoon Network's preschooler-aimed program Small World, which showcased animation from around the world.