Season 1 of In Treatment premiered on January 28, 2008.

In season one therapist Gabriel Byrne deals with five sets of patients, including an attractive woman with a crush on him, a scarred U.S. Air Force pilot, a suicidal teenage gymnast, and a couple on the verge of breaking up.

Season 2 of In Treatment premiered on April 5, 2009.

In season two, Dr. Paul Weston has divorced his wife Kate and moved from Maryland to a brownstone in Brooklyn, NY. Paul begins to rebuild his practice with a group of intriguing new patients while continuing to wrestle with some of the demons he left behind. Meanwhile, he commutes back to Maryland every Friday to continue his own sessions with Dr. Gina Toll.

Season 3 of In Treatment premiered on October 25, 2010.

In season three, Dr. Paul Weston deals with several new emotional and physical challenges. Meanwhile, he begins treating three new patients while seeing a new therapist of his own.

Season 4 of In Treatment premiered on May 23, 2021.

In season four, Dr. Brooke Taylor helps a diverse trio of patients navigate a variety of modern concerns and issues such as the global pandemic and recent major social and cultural shifts – all while she deals with complications in her own personal life.