As Sykes begins his end game, the agents discover that Helena is still alive... and teaching high school literature. Meanwhile, Jane reveals the full extent of her plan but one agent will lose their life carrying it out.

In the aftermath of the warehouse's destruction, the Warehouse team races against the clock to find a way to undo time itself and put right what went wrong. However, Artie finds himself facing a difficult decision when he is warned that saving the warehouse will unleash an even greater evil.

While Pete and Myka investigate a series of artifact-related growth spurts, Artie reluctantly takes Steve and Claudia with him to track down Brother Adrian before he can steal more artifacts from the warehouse.

While Pete and Claudia travel to Oregon to look for an artifact used to kill enemies of the environmental movement, Artie deals with the repercussions of Leena's death.

While Pete and Steven check out a life-threatening incident at a renaissance faire, Myka agrees to help Claudia revive her comatose sister. However, they discover that doing so has unexpected consequences that threaten the warehouse and everyone in it.

The alternate-timeline Valda makes his move, using Claire as his mindless slave. As Valda sets out to move Warehouse 13 to a new location that he can control, the team races desperately to stop him before it's too late.