In Spain an unscrupulous mine owner plans to evict a farmer and his family from their property by using force. The Ghostbusters must help, but when the ghost of Don Quixote appears they question whether or not they can trust the aid of a ghost.

The evil ghost Harpoon and his hip full of pirates kidnap the ghost of Moby Dick and they ghost of Captain Ahab. With Moby Dick in his power, Harpoon plans to capture space liners and continue plundering. The Ghostbusters learning of this race to rescue Moby Dick and Captain Ahab.

The Ghostbusters travel to a Moon Colony in the future to help install an anti-ghost security device. Whilst there they meet Keyta, a little girl with a penchant for false alarms. However when Keyta sees two vampires disguising themselves as humans can she get anyone to believe her?

The Ghostbusters, in an effort to get away from it all, take a vacation in the wilderness with Corky. However, the evil ghosts Benny and Clyde have stolen a statue for Prime Evil and are hiding out nearby. When Corky is captured by the gruesome twosome the Ghostbusters rush to his rescue.

Prime Evil desires to locate a decoding box that was accidentally dropped from space into the ocean. With the decoding box in his possession he believes that he could use it to learn every secret that the Governments of the world possess. When a new submarine is revealed to have been built Prime Evil sends Captain Long John Scarechrome to steal it.