Jed pretends to be sick so that Granny can get to doctoring and feel more at home. Mr Drysdale and his physician, Dr. Clyburn get pulled into the ploy and Granny's mountain medicine is put to the test by a city doctor.

After Granny cuts off the top of Drysdale and Clyburn's (his doctor) hair for some homegrown remedy, Clyburn tries to keep her from ever doctoring again. Meanwhile, the Clampetts are looking forward to the Possum Day parade, which of course isn't celebrated in Beverly Hills, so Drysdale has to figure out how to have one to keep them happy. Granny also gives the men some of her hair growing potion.

Granny has a cure for the common cold & opens up an office in Mr Drysdale's Building.

Granny wants to retire from Doctorin' & go home to the Hills. She wants to pass on her knowledge to Jethro & Elly but they aren't really interested. Mr Drysdale convinces Dr Clyburn to ask Granny for advice so she'll stay in Beverly Hills.

Granny mixes up a batch of her 'spring tonic' & takes it to the bank. Jed swaps it for root beer. Dr Clyburn wants to charge Granny with dispensing without a licence. Mr Drysdale begs him not to & asks him to invite Granny to his surgery to see how modern medicine is performed. Against his better Judgement he agrees & invites Granny to his office. Granny thinks it's a date & Dr. Clyburn is interested in her. It's his day off but he's showing her all the modern devices, Granny wonders why he has no patients. Later Granny goes on TV advertising his services to get him some patients.