Season 1 of Brotherhood premiered on July 9, 2006.

Michael returns home after seven years on the run and reestablishes his criminal empire. Tommy tries to stay on the straight and narrow while representing his district. Eileen cheats on her husband and descends into drug addiction.

Season 2 of Brotherhood premiered on September 30, 2007.

Michael struggles to recover from a brutal beating while consolidating his power. Tommy maneuvers to win reelection as he distances himself from his brother's criminal activities. Rose sows unrest between her sons.

Season 3 of Brotherhood premiered on November 2, 2008.

Michael tries to avoid being whacked when his nemesis is released from prison. Tommy gets passed over for the House speakership and must rebuild his political career. Rose's health deteriorates.