《吾妻十三点》是以嬉笑怒骂、讽刺幽默的手法，反映现代人对婚姻的态度。

小说及专栏作家金银珠﹝郑裕玲饰﹞富于幻想，敏感多疑。珠双亲去世后，遗下房子和小量财产，故生活无忧，还可供男友出国深造。岂料男友变心，珠被抛弃。及后，珠与房客钟济财﹝林立三饰﹞互生情愫，更结为夫妇，恩爱非常。

珠密友陈美娟﹝余绮霞饰﹞婚姻生活不如意，对珠又羡且妒，不时兴风作浪，令珠、财误会频生，珠怀疑财与房客刘嘉丽﹝吴家丽饰﹞有染，适逢珠中彩票，更怀疑财会谋财害命。

珠生意外，众以为她已死，于是珠决将计就计，以自己孖生妹妹之身份出现，决查个水落石出。

房客危楼﹝冯伟林饰﹞本对珠有爱意，对珠之死伤心不已，见其妹出现，决义不容辞助珠查财杀妻之证据，惹出不少笑话。

The novelist and columnist Jin Yinzhu (played by Cheng Yuling) is full of fantasy, sensitive and suspicious. After Zhu's parents passed away, they left behind a house and a small amount of property, so they can live comfortably and allow their boyfriend to study abroad. Unexpectedly, her boyfriend changed his mind and Zhu was abandoned. Later, Zhu and the tenant Zhong Jicai (played by Lin Lisan) fell in love with each other and became a couple. Zhu's close friend Chen Meijuan (played by Yu Qixia) has an unsatisfactory married life. She is envious and jealous of Zhu. Life. Zhu had an accident, everyone thought she was dead, so Zhu decided to use her plan and appeared as her twin sister to find out the truth. The tenant Wei Lou (played by Feng Weilin) ​​originally loved Zhu, and was very sad about Zhu's death. Seeing his sister appearing, he was determined to help Zhu find out the evidence of killing his wife, which caused a lot of jokes.