Brock and the Venture family are on the run from the Law, the Monarch, Sgt. Hatred and the entire O.S.I.! Only bald ingenuity and an unlikely ally can possibly save their necks from the deadly noose tightening around the Venture Compound.

Brock Samson is a marked man.

A series of cryptic clues sends Team Venture out to uncover a mystery left by the late Jonas Venture, Sr. As each new solved riddle exposes one more piece of secret Venture history.

The Monarch launches his first attack on his new arch nemesis, the other Dr. Venture. But Jonas has the formidable defenses of Spider-Skull Island on his side, as well as his own Team Venture.

Determined to honor the father he never knew, Jonas Jr. converts Spider Skull Island into a Team Venture Museum. Unfortunately, he invited all of his father's surviving friends and enemies to the grand opening.

Bored and under-whelmed with his new Guild-assigned arch-enemies, The Monarch seeks to re-spark his old hatred by secretly visiting the Venture Compound while Dr. Venture is away at the Science Now conference.

All basements are kinda spooky, but the Ventures are about to learn the hard way that beneath the foundations of the Venture Compound lie deep, dark secrets.

Love is in the air, kind of, when Dr. Venture encounters his childhood friend, Dr. Tara Quymn, in the Amazon Rain Forest.

Dr. Venture, in a bid to make some much-needed money, opens up the compound as "Rusty's Day Camp for Boy Adventurers." But while the children are kept busy with activities.

As The Monarch and Dr. Mrs. The Monarch settle into their new home and a new, no-more-arching-Dr.-Venture anymore life, Dr. Venture receives an unorthodox introduction to his new Guild-assigned nemesis.

At long last, The Venture Bros. peels away the onion-like shrouds of time for a look back into the troubled past of America's most beloved hydrocephalic former boy genius.

Dr. Venture learns that a life with no arch enemy is not nearly so sweet when he finds himself besieged by C-list pretenders to the Monarch's throne, and his super-science business once again on the rocks.

The wait is over. The truths and half-truths about Dr. Venture's former arch nemeses, Dr. Girlfriend and The Monarch, are finally revealed (albeit obliquely) in an episode spanning twenty years.