Shiro Kazami corredor del Club de carreras de Tachibana, ve como un hombre al que socorre se derrite delante de él, lo que provocara que alguien atente contra su vida en múltiples ocasiones. Tras uno de estos intentos fallidos acude a su amigo Takeshi Hongo que sospechara que ocurre algo que podría destruir la paz adquirida tras la caída de Gel-Shocker. Después de ver como nuevamente atentan contra la vida de Shiro, Hongo descubre a unos encapuchados en una tumba que lleva su nombre. Shiro socorrerá a una joven llamada Junko Tama, perseguida por estos siniestros personajes, llevándola al hogar de los Kazami, que será asaltado por un mutante llamado Scissors-Jaguar, asesinando a los padres y hermana pequeña de Shiro dejando este de lado su buen corazón y jurando venganza contra los asesinos de su familia... Más tarde Hongo y Hayato descubrirán que detrás de esta nueva organización llamada Destron se encuentra un viejo enemigo.

Después de esquivar la muerte al convertirse en el nuevo Kamen Rider V3, gracias a la ayuda de los dos anteriores Riders (2x01), es enviado al cuartel general de estos a proteger a Tachibana de Scissors-Jaguar mientras ellos se enfrentan al mutante Kame-Bazooka. Shiro consigue proteger a Tobei pero no logra vengarse del asesino de su familia que consigue huir. Más tarde, averiguara el malvado plan de Destron para hacer explotar una bomba nuclear dentro de Kame-Bazooka en mitad de Shinjuku que será detenido gracias al sacrificio final de Kamen Rider Ichigo y Nigo...

El director de un hospital es convertido contra su voluntad en Tv-Fly el nuevo mutante de Destron y toma el centro como Hospital de la malvada organización. Mientras Tobei muestra a Shiro una tienda de deportes que será la nueva base secreta del Escuadrón Kamen Rider. Tv-Fly usando su poder de hipnosis controla a toda la gente del hospital y prepara una emboscada contra Kamen Rider V3 para estudiarlo y crear al cyborg perfecto para destruirlo, tras lo que construyen al mutante Fire-Squid. Mientras, Tobei se dirige a sabiendas a una trampa que Destron les ha preparado para averiguar algo sobre ellos y su malvado plan.

Shiro es derrotado por Fire-Squid y encerrado en un ataúd dentro de un crematorio en llamas, del que sorprendentemente huye con vida. Al mismo tiempo Tachibana vaga por una carretera amnésico tras ser hipnotizado por Tv-Fly y es socorrido por un conductor cuyo hermano pertenece al Rider club y reconoce a Tobei. Lo regresan al hotel donde se hospedaba y es de nuevo hipnotizado por el malvado mutante para asesinar a Shiro cuando se encuentre con él tras enviarle Junko en su busca...

El Doctor Murayama investiga una nueva fuente de energía segura para reemplazar la nuclear cuando Destron envía a Machinegun-Snake y ataca al científico sin lograr conseguir su preciada investigación. Su próximo objetivo para obtenerla será la ayudante de Murayama que al comprar un regalo para su hijo Tsutomu en la tienda de deportes Tachibana pierde su cartera y es recogida por Shiro que pretende devolvérsela. Mientras celebra con su hijo el cumpleaños de este el malvado cyborg aparece y secuestra a la madre del muchacho que junto a su amigo Mamoru intentará pedir ayuda cruzándose con Shiro en vano al no saber nada esté de su situación. Mas tarde V3 se enfrentará al letal hombre-serpiente, tras asesinar a Murayama y mientras persigue a los dos muchachos, siendo herido de gravedad en una pierna.

Machinegun-Snake antes de ser eliminado por V3 hiere de un disparo a Mamoru momento en el que aparece Jellyfish-Hammer otro de los malvados mutantes de Destron y se enfrenta al Rider, que huye para salvar la vida del joven. Más tarde en la base de Destron intentan sonsacar la investigación del difunto Doctor Murayama a su asistente, la madre de Tsutomu, quien se niega a revelarla siendo el siguiente paso de Jellyfish-Hammer secuestrar a su hijo para que revele la información. Mientras, Mamoru es hospitalizado y cuando su hermana mayor llega culpa a Shiro y al resto de su estado siendo esta abordada en secreto por el malvado mutante para que los traicione y secuestren a Tsutomu...

El Dr. Kawai consigue la proeza de devolver a la vida a un hombre que llevaba dos días muerto. Una de sus ayudantes avisa a Destron quien mata al resto de colaboradores e intenta secuestrar a Kawai en vano, huyendo este junto a su hijo Tadashi del incendio de su hogar. Más tarde un extraño hombre vestido de negro ronda la ciudad en busca de Kawai y su hijo, quien llega a conocer a Shiro y pone a este al corriente de su situación. Tras prometer ayudarle el Rider encuentra y se enfrenta a Knife-Armadillo y es superado. Un malherido Shiro pedirá a Tachibana un entrenamiento extremo para superar a su rival.

Knife-Armadillo ataca a Tachibana y V3 durante el entrenamiento extremo que realizaban ambos, siendo eliminado por el Rider gracias a este. Mientras, Buzzward-Lizzard quien en realidad es la antigua asistente del Dr. Kawai, logra coaccionar a este para que reviva al defenestrado mutante amenazando a su familia y obtiene la información de que V3 se recupera de su enfrentamiento en el hospital. Esto en realidad se trata de una artimaña de Tachibana y Shiro para ser capturado por Destron, encontrar su base y salvar a Kawai junto a su familia de las garras de sus archienemigos.

Kazami Shiro's rival, Yoshioka Masaru, and other top racers in the All Japan Motorcross Championship, are captured by Destron's Lens-Ant. He transforms them into the Destron Hell Squad in order to rob a convoy carrying a nuclear-powered satellite. The mutant also captures Junko and Shigeru! Will Shiro save his friends? Can V3 defeat not one, but two mutants, single-handedly?

Destron's Razor-Starfish teams up with Lens-Ant to attack V3, and they send the Hell Squad to steal a shipment of nuclear satellite fuel. Meanwhile, Tachibana Tobei and the Rider Scouts are captured while searching for Junko and Shigeru. Can Kazami Shiro find the antidote for the Hell Squad, rescue his friends from certain death, and take on both mutant cyborgs?

Destron forces Marine biologist Dr. Nakatani to create a powerful aquatic mutant, Pickaxe-Shark. The doctor escapes, but his creation is sent to kill him. Meanwhile, a chinpira exposes Kazami Shiro's secret identity to Junko, but is captured and transformed into Drill-Mole. As V3 battles Pickaxe-Shark in the open sea, Drill-Mole abducts Junko to force her into an unholy union!

Destron's Pickaxe-Shark proves a formidable foe to V3, who suffers defeat at the claws of the mutant. Meanwhile, Junko is prepared for an unholy union with Drill-Mole... Can Kazami Shiro recover in time to defeat Pickaxe-Shark and rescue Junko from a fate worse than death � while guarding his secret identity?

A couple hikes into the mountains to research the secret of the legendary Boar-Man, but only the woman returns. Suspecting Destron, Kazami Shiro goes to the hospital, only to have the missing man reappear � a disguise for Magnet-Boar, who aims to destroy Japan's national railway system. After an intense fight, Shiro discovers that he cannot transform into V3! But, this was simply a ruse to allow the sinister Doktor G safe passage into Japan...

Toad-Boiler attacks Interpol agent George Kamamoto, who is trying to pass on a coded document from Riders One and Two to Kazami Shiro. V3 saves Kamamoto, and then heads for Chichibu, as directed by the document. Toad-Boiler implores him to transform into V3, and then sprays him with a white fluid � a substance that drains V3's energy! Can V3 survive and obtain the secret left behind by the Double Riders?

The daughter of Dr. Okajima, an atomic physicist who escaped the clutches of Destron with the help of the Double Riders, saves the badly injured Kazami Shiro from the basin of a waterfall. She is then stalked by Burner-Bat, who is looking for V3. With the help of Dr. Okajima, Shiro is able to find the memento from the Double Riders, which holds the secret to V3's four weaknesses. What are they?

Rider Scout Saburo and his father save a hapless fisherman, whom witnessed mutant Missile-Gecko in action. V3 fights off Missile-Gecko, but meanwhile, Destron snatches Saburo and his father. When Saburo discovers Destron's plot to destroy the petroleum complex, will he be able to contact Rider Scout HQ? Can V3 save Japan from plunging into total chaos?

The fearsome Spray-Rat takes on the likeness of a priest and finds a young couple to use as guinea pigs for his Devilspray virus. He offers to marry them, but only allows one witness � Tama Junko. Kazami Shiro arrives in the nick of time, but cannot prevent the groom from being infected. While rescuing the bride, V3 is trapped in a church with a ticking time bomb! Can V3 escape deadly doom?

Kusarigama-Beetle captures Kazami Shiro and takes him to Destron's outpost. While Doktor G is torturing Shiro he breaks free and seizes the files for the Devilspray antidote � only to discover that it is a fake! V3 is ambushed by the Destron mutants, and in the heat of battle Spray-Rat attacks Kusarigama-Beetle. The injured mutant decides to betray Destron and help Shiro retrieve the antidote for the Devilspray. But, is V3 being lead into a trap?

Kazami Shiro rushes to Tatsunoko Point where Destron has been sinking passing ships, in a bid to seize control of the seas. After encountering Blowfish-Apache's torpedoes, Shiro discovers slaves working in a secret weapons factory. With the help of Tachibana Tobei, Shiro is able to penetrate the Destron outpost, but they are led into a deadly trap, and sunk to the bottom of the sea! Can V3 save Tachibana and stop Destron?

Destron uses the SS Device flown in from their South American base, in an attempt to conquer the island of Shikoku. Fukazawa, a scientist forced to work for Destron, manages to escape with the schematic. When Kazami Shiro receives word, he heads immediately for Shikoku via ship, but is attacked by Guillotine-Saurus. Can V3 break through and save Shikoku from Destron's grip?

V3 is saved by the voices of the Double Riders coming from a special medallion. In Shikoku, Kazami Shiro disguises himself as a Destron sympathizer to repair the SS Device. Meanwhile, Fukazawa, Tachibana Tobei and Tama Junko fall under the control of Syringe-Spider! Can V3 stop Doktor G's conquest plans and find the antidote to save his friends from the clutches of Destron?

The Rider Scouts are at training camp on Hatsushima Island, where mutant Speargun-Sea Lion has established an undersea outpost to manufacture poison gas. Destron plans to transport the chemical weapon via an underground canal to Mt. Fuji, where the winds will spread the gas over hundreds of miles. Kazami Shiro orders the scouts to evacuate, but they refuse when they realize one of them is missing. Can V3 stop Destron in time?

Propeller-Beetle begins kidnapping young people � the males are reconstructed into Destron Soldiers, while the blood of the females satisfies his energy source. When the monster hears the voice of the sister of Kazami Shiro's friend Kuroda Kyosuke, he retreats. When she discovers that her brother is really Propeller-Beetle, Doktor G orders the mutant to drink her blood. Kazami enters the Destron outpost when Junko is captured. Can V3 save them?

In order to wage germ warfare on Japan, Destron takes over the Osato Biological Institute and tortures the head scientist, to pillage his research. Meanwhile Rider Scout Yoshio notices that young women go into the institute but don't come out. So he snoops around to check things out, but is captured by Cockroach-Spike. Junko goes in to rescue him posing as a housekeeper, but is also caught spying. Can V3 thwart Destron's plot?

Rumors circulate of savage ape-men in the Omi Mountains, but this is a cover for training Destron's Ranger Squad units. In order to keep this secret Mantis-Merang kills anyone who approaches the area. V3 saves Rider Scout Kenji and his older brother from certain death, but the Destron Rangers soon surround them. Meanwhile, the 2nd Unit of the Destron Rangers starts tainting Tokyo's water supply with the deadly Mummification Virus�

With the Mummification Virus in Tokyo's water supply, Destron plans to turn 10 million people into mummies, using Heater-Cicada's chirp to drive victims to drink the tainted water. Kazami Shiro discovers that Professor Taguchi is the only person who can create an antidote and saves his daughter while trying to rescue Junko. But is the professor's daughter really who she says she is? Has Shiro fallen into a trap?

Rider Scout Shotaro has discovered Shocker mutants entombed in a lakeside cave. When he arrives, the mutants are gone, but Kazami Shiro is ambushed by Destron's powerful Quoit-Beetle. Destron plots to destroy the whole of Japan by resurrecting former Shocker Commandants Colonel Zol, Doctor Death, Ambassador Hell and General Black, using a newly developed toxic gas called Girard Gamma. Suddenly, V3 is attacked by the revived Shocker mutants, led by Quit-Beetle!

Trapped by the five commandants Kazami Shiro falls into an unbreakable cell. Tachibana Tobei, in a bid to rescue Shiro, poses as a scientist who has developed an antidote to the nerve gas, and is abducted. Meanwhile, Shiro turns the table on Ambassador Hell and takes him hostage in order to escape. But, he must infiltrate the outpost once more in to rescue Tachibana and Junko. Can V3 save Japan, as well as his friends, from certain death?

Held responsible for the death of the Shocker Commandants, Doktor G creates Camera-Mosquito, who steals people's faces in a last-ditch effort to take control of Japan. Meanwhile, Destron Hunter Sakuma Ken steals microfilm containing Destron secrets and becomes the target of Camera-Mosquito. Kazami Shiro saves Sakuma and takes the microfilm to Professor Tadokoro for decoding, but Camera-Mosquito has already stolen his face� Can V3 prevail?

The Destron Hunters discover that the microfilm gives the location of a manufacturing plant where Destron creates their mutants. While they succeed in sabotaging the plant, Doktor G arrives to exterminate them, except for Sakuma Ken, who is saved by V3. Doktor G implores the Great Leader to allow him to destroy V3 personally, and transforms into Crab-Laser. Will this be the end of Destron� or Kamen Rider V3?

The Great Leader summons Baron Fang, the great Doovoo shaman of the Tusk Tribe from the upper reaches of the Congo River, to become commandant of Destron Japan. His mutant Skull-Warthog uses his tusks to dissolve human flesh from their bones. In order to lure Kazami Shiro to his doom, Skull-Warthog possesses the body of Rider Scout Toshiko's father and kidnaps her mother. Shiro and Sakuma Ken come to her aide, but are soon surrounded by the villagers who fall under the sway of the Devil's Drums�

Given the task of destroying the Rider Scouts, Fireball-Walrus possesses Tachibana Tobei's old friend Ito, the manager of the mountain villa where the scouts go on retreat. When Junko discovers his true identity, she is also marked for death. When they are attacked, V3 comes to the rescue, but not only must he fight Fireball-Walrus, but he also comes face to face with Baron Fang. Who will triumph?

Dr. Samukawa and his daughter Yumiko are put under pain of death by Snow-Wolf to assist Destron to pervert his scientific discovery. Baron Fang places a lycanthropic curse on Yumiko, which transforms her into a werewolf if they do not obey his will. She drugs Junko, Shigeru and Tachibana who are taken prisoner, while Snow-Wolf defeats Kazami Shiro. Frozen in an ice chamber Shiro is unable to transform into V3� who will save them?

Baron Fang resurrects Smilodon the sorceress and ancient mother of the Tusk Tribe in order to destroy the Kamen Riders. Taking on the name Ayanokoji she delivers a voodoo doll that poisons Hongo Takeshi who is taken to a hospital. When Kazami Shiro rushes to the scene she attacks him as Primordial-Tiger, who manages to subdue V3 and locks him up with Hongo. She then targets Ichimonji Hayato� can Hayato free his comrades and best Smilodon?

A Destron fugitive calls Rider Scouts HQ to reveal a sinister plot, but the line goes dead. Discovering a locker key at the scene, Kazami Shiro is ambushed by Bloodthirsty-Mammoth, but escapes. Shiro retrieves photographs of three members of parliament whom Baron Fang plans to brainwash in order to conquer Japan. So he disguises himself as one of the men and is taken to Destron's outpost. Can V3 stop Baron Fang's diabolical plot?

Destron summons Archbishop Wing and his clan from Tibet to take over where Baron Fang failed. Soon afterwards a strange Buddhist monk claims that evil spirits reside in the homes of the president of an industrial factory and the director of an atomic research facility � the evil spirits turn out to be mutant Flame-Condor. When V3 is injured in battle, Tachibana Tobei helps him to train against the airborne menace. Can V3 overcome the odds?

Archbishop Wing's Dryad-Flying Squirrel is able to turn a red fluid that he secretes from his claws, into a deadly gas that transforms humans into flying squirrel carcasses. His plan is to spread the gas far and wide in a violent eruption of Mt. Daisetsu. The mutant plans to use V3 to set off the explosives by kidnapping Shigeru, his cousin, and his grandfather. Will V3 trip the explosives or will he outwit Destron?

Mutant Poison-Mothla kills two power company workers who discover electricity being re-routed. Meanwhile, Destron captures the father of a young boy, Tsuyoshi, who stumbled upon their outpost. Kazami Shiro arrives to investigate the siphoned power, and finds the boy all alone. Trapped in the valley by Destron, V3 fights Poison-Mothla, but cannot defeat him. Can V3 find the creature's weakness and reunite father and son?

Archbishop Wing plans to use the poison of the inhuman Plantaingan, combined with 30,000 volts of electricity, to create miniaturized people preserved for use in creating cyborgs. The mutant kidnaps a young boy's sister and Kazami Shiro must fight in order to save her. Plantaingan attacks Rider Scouts HQ to liquidate a captured Destron Soldier and threatens Tachibana Tobei and Company. Can V3 liberate them from the tendrils of death?

Destron mutant Deadman-Bat, employing a virus called the Himalayan Devil, turns the residents of apartment complexes in all the major cities into vampire slaves. When Rider Scout Kiyoshi discovers his older brother is one of the victims, he and Shigeru are attacked by the mutant. V3 challenges Deadman-Bat, but is tossed from the air and Kiyoshi is injured. Can V3 develop a new technique in order to defeat the true form of Archbishop Wing?

Summoned from Mongolia, Marshal Armor becomes the new commandant of Destron Japan and employs Nazi transplant technology to create the invulnerable Pumadillon. Marshal Armor releases a slave named Yamashita to contact Kazami Shiro to lure him into a trap. Kazami's old friend Takagi Yusuke work together to protect Yamashita and his family, but something is very wrong � Takagi begins to praise working for Destron�

Marshal Armor's Snailbura implants its sinister eggs into the residents of an apartment complex. These incubate in the victims' bloodstream developing into larvae to enslave them. Snailbura's first experiment is ordered to kill Kazami Shiro, but dies before she can complete her mission. Her sister Misako accuses Shiro of murder and Snailbura promises to give her the power to avenge her sibling's death�

V3 saves Riderman from Sickleneck-Tortoise's nerve gas in the nick of time. Regardless Riderman doesn't want to listen to V3's words against Destron � he only seeks revenge against Marshal Armor. Meanwhile, Marshal Armor begins his plan to spread the nerve gas and begins killing innocents throughout Tokyo, and while Kazami Shiro investigates with Yuki Joji right on his tail, Sickleneck-Tortoise stalks them both�

Marshal Armor sends mutant Rhino-Tank, disguised as Santa Claus, to lure children into the House of Good Fortune, in order to train them as future Destron commandants. Yuki Joji finds this disturbing and "Black Santa" offers to release the children if Joji will defeat V3. In order to save the children, he decides to fight V3 with Rhino-Tank. After the Mach Kick and the Hurricane Dash fail to faze the mutant, an industrial bulldozer slowly crushes V3�

Pinned against a cliff by a bulldozer V3 uses his Reverse Double Typhoon to save himself and infiltrates the Destron outpost. He saves Yuki Joji who was trapped in an execution chamber, but Destron mercilessly pummels V3, who was injured in his battle with Rhino-Tank. Yuki finally sees Destron's cruelty, but will he rescue V3 or the kidnapped children? Which way will Riderman go�?

A New Year's card from Marshal Armor arrives for Yuki Joji, so he and Kazami Shiro investigate the return address. When they split up and enter the manor, Coelacanth-Kid attacks V3 and Riderman falls into Marshal Armor's hands. The mutant takes on Joji's form, becoming "Destron Riderman" in order to wipe out Shiro and the Rider Scouts. Shiro is tricked by the fake Joji and is thrown off of a cliff! Then the evil imposter makes his way to Rider Scouts HQ�

The Great Leader, overlord of Destron, arrives in Japan. When V3 and Riderman go after him, they fall into a trap. Meanwhile, Destron mutant Thorned-Starfish puts into action his plan to annihilate Tokyo. In the grip of suffocation, V3 and Riderman are saved when Tachibana Tobei comes to their aid. V3 and Riderman fight Thorned-Starfish, but when V3 turns to take on the Destron Leader, Riderman suddenly takes a stand to defend him�

Destron mutant Chameleon shoots Yuki Joji, but Kazami Shiro takes the bullet. Soon Shiro becomes unable to control his strength and becomes a menace. Meanwhile, Chameleon's human form uses a naive country girl to ensnare the vulnerable Shiro. In order to remove the Vatal Bullet from Shiro's skull, they must infiltrate Destron's Tokyo outpost. But, Marshal Armor and Chameleon are waiting to welcome them�

Mutant Chameleon is resurrected as Vampire-Chameleon and Marshal Armor sends him on a mission to collect the blood of innocent children. Kazami Shiro befriends young Kenichi, who is despondent because he believes that he has seen a mutant. When Vampire-Chameleon attacks Kenichi's grammar school, Shiro and Joji find themselves in a dilemma, when they face a horde of vampire children they cannot kill�

Marshal Armor has developed a powerful Pluton Rocket that is more powerful than the H-Bomb and the Great Leader orders that it be aimed at Tokyo. Shiro and Joji become suspicious when a group of mountaineers are killed mysteriously in a remote valley. While investigating, they are attacked by mutant Crawganna who protects the Destron missile base. But, V3 and Riderman fail to stop Marshal Armor from starting the cataclysmic countdown�

The Great Leader initiates "Operation: D", a final, all-out offensive to seize control of Japan. Destron revives Deadman-Bat, Fireball-Walrus and Plantaingan who attack Rider Scouts HQ and kidnap Junko and the Scouts. Meanwhile, Kazami Shiro has discovered Destron's headquarters where dwells the Great Leader, but the mutants bury him in a mound of dampening powder made from special alloys. Even if V3 escapes their trap, Crawganna awaits�