Kaguya Otsutsuki suddenly descends from the heavens as the people of the Land of Sou look on in surprise and suspicion. But their king, Tenji, is enthralled by her and takes her for his concubine. In this age of endless war, Kaguya wishes for nothing but peace. But as the self-proclaimed protector of the Divine Tree, she soon finds herself engulfed by the tides of chaos and war.

Hagoromo sends the brothers to two battle-scarred regions left untouched since the fight with Ten Tails. He then announces that he will choose his successor depending on the outcome of their missions.

Ashura sets out on a journey, intending never to return. He ends up in a village where the people suffer from a mysterious illness.