Pietro, Edoardo, Stefano and Sergio follow an important anti-drug operation that will lead directly to the top of a criminal clan. Elena Baroni, following a visit from her father, decides to have dinner with him feeling a rebirth of empathy. During dinner, however, disagreements begin again and Elena turns away in annoyance. A few moments later, gunshots reach Judge Baroni.

Elena investigates her father's death and, rummaging through his belongings, finds an anonymous letter in which the son of a convict accused the judge of having killed his father, Gennaro Barreto, innocently in prison. The woman finds Nicola Barreto and kills him. The police investigate her murder and Pietro Guerra discovers that her culprit is her partner Elena di lei: Pietro will therefore find himself arresting her.

The body of a doctor is found lying in the street: investigations show that the young doctor, active in volunteering and apparently blameless, had actually shot him shortly before being killed, had recently withdrawn twenty million from his account and asked for a credit line from the bank and frequented a prostitute. Meanwhile, Pietro Guerra experiences a deep inner conflict for having Elena arrested. Regina Orlando arrives at the police station, the new deputy commissioner.

Antonio and Laura stop two criminals on board a lorry and, inspecting the vehicle, they find a stolen Porsche whose seats are stained with blood and whose owner has mysteriously disappeared. Pietro, Sergio and Eduardo investigate the boy and discover that he used to go to seedy nightclubs.

Strangers set fire to the car of Professor Attilio Lanza, a well-known criminologist. Nava and Amato are involved in the investigations under the supervision of Deputy Commissioner Orlando: the culprit could be a former patient of Lanza's, but the investigations will lead to a totally unexpected solution to the case.

The agents of the police station are engaged on numerous fronts: Inspector Guerra investigates cases of counterfeiting in Naples, Commissioner Cafasso teaches undercover in a high school to unmask a gang of petty thieves, while the other agents investigate what is happening at the Galvax factory where various accidents take place before this is sold.

Fajid, a Kurdish child, is found charred after his parents report him missing. Meanwhile, a girl arrives at the police station to report the sexual harassment of which she has fallen victim, but the man accused of the violence says he is sure he can emerge from this affair without a clean record.

Eleonora Soriano, the rich 46-year-old daughter of a well-known industrialist, is found dead in her apartment. The first suspicions about her fall on her husband who was having an affair with his wife's best friend.

An agent of the commissariat infiltrates an art laboratory and pretends to be a model to make friends with a painter who is very skilled in reproducing paintings. A few days later the girl is found murdered and investigations lead to the discovery of a connection between the theft and trafficking in Japanese antiques. Meanwhile, Pietro Guerra is on the trail of a large batch of ecstasy.

The team is on the trail of a gang that steals goods from trucks under the guise of policemen. Peppino Tucci, their boss, before being arrested accused Sergio Amato of hitting him during an interrogation. Carlotta Santarcangelo, detained daughter of a boss who in the past had tried to kill Fabrizio Nava, asks him to forgive her.

Luciano and Katia, following an anonymous phone call announcing a murder at the zoo, go to check and find a doll with a torn body. The game repeats itself and it turns out to have been worked out by a criminal mastermind as part of a larger and more ruthless plan. Stefano and Sergio instead investigate a case that has to do with the world of pornography.

The police station receives an anonymous tape with video of a man strangling a woman. Sergio and Antonio go to the scene of the crime, an art school, but one of the associates tells them that it is rehearsals for a show. Meanwhile, however, the protagonist of the video has disappeared. Regina Orlando is determined to frame Palizzi, rival chieftain of the Terenzis.

Police officers are investigating a new synthetic drug that is claiming many victims among teenagers. Giancarlo Anelli, Pietro's companion at the police academy, assists the search, but kills the key witness under suspicious circumstances. Fabrizio works on a possible case of circumvention of an incapacitated woman by a beautiful foreigner against an elderly man.

Tania and Sergio prepare for the wedding. Luciano and Laura investigate the assault on a woman and discover a family reduced to poverty due to their obsession with gambling, favored by an unscrupulous criminal who runs a network of clandestine gambling dens.

Lucia Pistrozzi tries to help a friend involved in a bad ride, but is sucked into it in turn. Fabrizio will intervene to resolve the situation. Sergio and Tania get married and Regina also participates in the wedding, accompanied by Guido.

The body of a promising young swimmer, Renato Moretti, is found lying in the pool. Inspector Nava investigates together with two agents and discovers that the boy, convinced by a friend, had started using performance-enhancing substances. Then comes the missing report of Tatiana Crocco, a fourteen-year-old girl, who ran away from home due to the constant quarrels of her adoptive parents.

During the investigation into the Santarcangelo clan, Pietro Guerra is seriously wounded in the head. The team lives moments of great anguish. Meanwhile, Orlando and Amato continue their investigations and manage to find the right lead also thanks to Carlotta Santarcangelo, detained in Poggio Reale and in love with Fabrizio Nava.

Regina Orlando visits the orphanage where she grew up, who lives in a difficult economic situation. Meanwhile, in the garden adjacent to the orphanage, mysterious events take place which Fabrizio and Stefano are investigating. Scary events involving some students occur in a pub: the Sant'Andrea police station sets to work to find an explanation.

Antonella Cantamore, daughter of an old friend of Cafasso's, works in a luxurious brothel. The girl is kidnapped and Cafasso and Regina discuss the methods to be adopted to solve the case. Regina will find the right lead, but she will put Laura and Alfio's lives at risk.

Laura Onorato suffers serious eye injuries during an operation and discovers that she has a permanent lesion. The agents of the police station, while researching Jovine, a criminal expert in fraud, discover drug trafficking. Regina Orlando presents transfer application.

Jerry Tagmaouhi, co-owner of a club together with Mario Maggese, is attacked in the street by three thugs. At first glance it would seem a racist aggression, but Katia's investigations will lead to reveal a different reality. Edoardo and Fabrizio instead investigate the disappearance of a woman following an argument with her spouse.

A journalist working on an investigation into international arms trafficking is involved in the murder of a pensioner. Pietro and Sergio, after an attack by the journalist, decide to act as his escort while they investigate the case. Fabrizio and Stefano, meanwhile, investigate a clandestine car racing ring.

The Sant'Andrea police station is shocked by the suspicion that Stefano, one of the best agents, has become an accomplice to the Camorra: Fabrizio and Pietro work hard to prove his innocence. Meanwhile, Edoardo discovers the violence of Miriam's husband and promises to keep her secret and protect her.

Gennaro escapes house arrest and returns home mortally wounded; shortly after, his nurse also dies, from poisoning. The investigations of the police station try to discover the link between the two crimes. The agents also investigate the theft of a company car and some jewelery designs, bringing to light the work of a prostitute who robbed her wealthy clients.

An intricate case that reveals a more disturbing truth than the agents had imagined: that of a young lawyer killed and his alleged killer, found dead of an overdose. The policemen of the police station are also investigating a gang of criminals who use the undergrounds of Naples to rob banks.

A child is found abandoned in a bad street: it turns out to be the son of a collaborator of justice kidnapped by the Camorra. The Sant'Andrea police station also investigates the murder of a university professor who reveals a scandal of exams sold and experiments conducted by the professor. In the meantime, the love story between Miriam and Edoardo continues, behind her husband Luciano.

A merchant, convinced by the policemen of the Sant'Andrea police station, rebels against the racket while one of the leaders of the Santarcangelo clan is killed. The trial of Carlotta Santarcangelo begins and Fabrizio has to testify. Marisa receives a suspicious fine and shows it to Antonio who discovers it to be fake.

The Santarcangelo clan is suffering the consequences of the war with the rival clan but none of its members seem to want to help the police with their investigations. When Carlotta Santarcangelo, accused of murder, she learns that her father was killed in prison and she decides to collaborate.

Edoardo Valle and Sergio Amato investigate the robbery of two elderly gentlemen found drugged in their apartment. The elderly were in possession of a large sum of money and suspicion falls on a group of boys who, posing as municipal operators, interview elderly people in order to get hold of information regarding their economic position.

The police officers of the Sant'Andrea police station are investigating to identify a gang of drug dealers who hide under false identities, it will be a report for harassing noises from a neighbor to lead the agents towards the discovery of the culprits.

An entrepreneur is killed in his textile company, he had previously had bitter conflicts with his workers who asked for better working conditions. Luciano, enraged by Miriam's request for separation, decides to contact a lawyer who can manage the paperwork.

The Sant'Andrea team is called to intervene following a report of a robbery but, despite the timely arrival of the agents on the spot, the robbers manage to escape. During the trial interviews, the idea of infiltrating a policeman within the Camorra was born.

The agents are on the trail of a gang of cigarette smugglers who circulate with powerful armored vehicles. Luciano, who has agreed to infiltrate the world of the Camorra, must quickly learn the rules to be able to survive in a criminal environment.

A narcotized girl is found on a hearse. she has no documents or any particular sign that could help identify her. While waiting for her identity to be revealed, she is nicknamed "Sleeping Beauty". Meanwhile, Luciano lives dangerously his new life as an infiltrator in a Camorra clan.

Two distinct cases intertwine in this episode: a trafficking of synthetic drugs and the disturbing murder of a boy belonging to a strange secret sect. Meanwhile, since Tania discovered she is HIV positive, she has been under constant medical supervision.

Preparations for a wedding in Naples end in tragedy when the bride is found murdered. It turns out that the woman had a double life that no one seemed to be aware of. Meanwhile, a traditional African festival arouses suspicion in the police officers.

A homeless person finds himself having a suspicious amount of money. When a merchant refuses to accept his banknotes, the man wounds him and runs away. The cops are looking for him in the places he used to frequent. In the meantime, Luciano joins the clan managing to win the trust of the boss.

At a checkpoint a boy on a moped is told to stop. After an escape and an accident, the investigations will reveal that it is a stolen vehicle. Meanwhile boss Mimmo Jovine begins to grow suspicious.

In the cavity of an apartment, the skeleton of an Albanian woman who lived in that house several years earlier is unexpectedly found. Investigations begin on a prostitution ring that guarantees a large profits to a criminal organization.

The investigations aimed at identifying the perpetrators of the attack on the Caruso bar are progressing with great difficulty. The most promising track seems to be getting information from a boy brother of one of the victims. The discovery of the body of a black man will be a further development.

One evening, looking out the window of his apartment, Walter Battiston sees a girl leaving the house being chased by an armed man dressed only in a towel. To block the man Battiston fires a warning shot into the air, but things don't go as hoped.

The kidnapping of a woman leads the police officers of the Sant'Andrea police station on the trail of the Assomma clan. Meanwhile, a girl is traumatized by an attempted rape by two men, in the context of a sports center she frequents.

The investigations of the police station are focused on a gang of young drug dealers in which a boy, eager to show off with the older ones, is recruited by a Camorra boss.

Fabrizio continues to see Carlotta secretly despite being warned by Cafasso not to see her to avoid the risk of exposing her to the revenge of the Camorra. The danger becomes real when the young woman joins her lover in Naples and is recognized on the street.

Pietro and Alfio were involved in the filming of a crime film. During the filming of an action scene, the protagonist is the victim of a serious accident due to the replacement of the prop weapon with a real one. Is it really an accident?

In a neighborhood of Naples, leaflets are circulated against a Rom camp. Subsequently, while checking a police station at the Sant'Andrea police station, a fire suddenly breaks out in the camp. The investigations will focus precisely on the authors of the flyers.

Amato collects a woman's complaint about her missing husband. The investigations will reveal that the man died in a car accident on a road that he should not have traveled and that he had also recently changed his shift. Analyzing his movements on his bank account, the agents also detect anomalous money payments.

A young violinist is murdered and among the suspects is a blind seer who had foreseen the crime. The agents investigate the connection between this crime and the misfortune that happened two years earlier to the daughter of the director of the conservatory attended by the murdered girl.

A taxi driver is attacked by a hooded man, it will only be thanks to the providential sound of an alarm that the man will flee. The girl was rescued by a witness who claims to have heard alarms go off in rapid succession and to have seen someone fleeing on foot.

A private detective is murdered, the main suspects in this murder are the protagonists of the two cases that the detective and his partner were following: the first investigation concerned a case of marital infidelity while the second an insurance scam.

On the day of the inauguration of a new multiplex cinema, the body of a man who turns out to be a Romanian laborer is discovered in one of the halls. The investigation into this murder will lead the agents to discover an illegal trade in workers managed by a criminal organization.

Agent Stefano De Pretis is accused of murdering a woman who had been his lover until a few months earlier. However, after the end of the relationship with De Pretis, the woman had fallen in love with a doctor dedicated to volunteering, with whom she planned to leave everything to go to Africa.

Two bodies are found in the botanical garden in two days: one belongs to the owner while the other belongs to a sports center doctor. After careful investigations, the men of the Sant'Andrea police station suspect that the two crimes are to be connected to the crime of a third person.

The explosion of a bomb in a cinema prompts the men of the Sant'Andrea police station to investigate what is believed to be a case of Islamic terrorism. Meanwhile, Inspector Ramaglia, starting from his wife's report for the constant absences of a schoolboy, investigates a series of incidents that have occurred in the market.

Inspector Valle and some colleagues witness a robbery while they are in the port area and manage to recover the victim's bag, but suddenly they notice that the bag could contain drugs.

The discovery of a voluminous wad of banknotes of uncertain origin sets off an investigation into a round of bribes while simultaneously suspecting drug dealing in a high school.

The shipyard where Alessia Moretto's father worked is about to cease its activities and the caretaker, fearing losing his job, would like to attempt suicide. The intervention of the men of the Sant'Andrea police station will be timely and providential.

A frightened child has lost his mother in a supermarket crowded with busy and distracted people. The men of the Sant'Andrea police station investigate the case but her mother seems to have apparently disappeared into thin air.

An elderly lady dies as a result of a mugging and the men of the Sant' Andrea police station who arrive on the spot carry out their investigations looking for eyewitnesses. No one seems to have seen anything, an anonymous phone call will provide some useful clues.

A strange accident occurs in a Luna Park: the gift that a mother has just bought for her son suddenly explodes. The owner of the kiosk where the mother bought the gift and a young photographer who may have immortalized the scene are immediately questioned.

A bomb explodes in the locker room during a rugby match between ex-convicts and custodial officers attended by Deputy Commissioner Cafasso, killing an unfortunate dog. Inspector Battiston decides to infiltrate the team to carry out accurate investigations.

Giorgio Pettenella manages to dismantle a Camorra organization following the complaint of a woman to whom a fake painting has been sold. Luciano Russo and Alessia Moretto investigate the death of a young woman, among the suspects a dance teacher and the owner of the tango school attended by the girl.

Investigating the death of the rich owner of a chain of ethnic shops, the men of the Sant'Andrea police station go back to an obscure story linked to the period in which the victim and his partner served in the Foreign Legion.

A woman is found along the side of a road in a state of total amnesia. The investigations lead to the discovery of the double life that the woman leads: both an affectionate wife and a transgressive lover. Meanwhile, a zoo attendant is found mauled in the lion's cage.

A pediatrician who surreptitiously transfers patients from public facilities to his private clinic ends up in the crosshairs of the police following a complaint from another doctor. Agent Moretto, posing as a doctor in turn, will carefully investigate the hospital environment.