Pietro, Edoardo, Stefano and Sergio follow an important anti-drug operation that will lead directly to the top of a criminal clan. Elena Baroni, following a visit from her father, decides to have dinner with him feeling a rebirth of empathy. During dinner, however, disagreements begin again and Elena turns away in annoyance. A few moments later, gunshots reach Judge Baroni.

Elena investigates her father's death and, rummaging through his belongings, finds an anonymous letter in which the son of a convict accused the judge of having killed his father, Gennaro Barreto, innocently in prison. The woman finds Nicola Barreto and kills him. The police investigate her murder and Pietro Guerra discovers that her culprit is her partner Elena di lei: Pietro will therefore find himself arresting her.

The body of a doctor is found lying in the street: investigations show that the young doctor, active in volunteering and apparently blameless, had actually shot him shortly before being killed, had recently withdrawn twenty million from his account and asked for a credit line from the bank and frequented a prostitute. Meanwhile, Pietro Guerra experiences a deep inner conflict for having Elena arrested. Regina Orlando arrives at the police station, the new deputy commissioner.

Antonio and Laura stop two criminals on board a lorry and, inspecting the vehicle, they find a stolen Porsche whose seats are stained with blood and whose owner has mysteriously disappeared. Pietro, Sergio and Eduardo investigate the boy and discover that he used to go to seedy nightclubs.

Strangers set fire to the car of Professor Attilio Lanza, a well-known criminologist. Nava and Amato are involved in the investigations under the supervision of Deputy Commissioner Orlando: the culprit could be a former patient of Lanza's, but the investigations will lead to a totally unexpected solution to the case.

The agents of the police station are engaged on numerous fronts: Inspector Guerra investigates cases of counterfeiting in Naples, Commissioner Cafasso teaches undercover in a high school to unmask a gang of petty thieves, while the other agents investigate what is happening at the Galvax factory where various accidents take place before this is sold.

Fajid, a Kurdish child, is found charred after his parents report him missing. Meanwhile, a girl arrives at the police station to report the sexual harassment of which she has fallen victim, but the man accused of the violence says he is sure he can emerge from this affair without a clean record.

Eleonora Soriano, the rich 46-year-old daughter of a well-known industrialist, is found dead in her apartment. The first suspicions about her fall on her husband who was having an affair with his wife's best friend.

An agent of the commissariat infiltrates an art laboratory and pretends to be a model to make friends with a painter who is very skilled in reproducing paintings. A few days later the girl is found murdered and investigations lead to the discovery of a connection between the theft and trafficking in Japanese antiques. Meanwhile, Pietro Guerra is on the trail of a large batch of ecstasy.

The team is on the trail of a gang that steals goods from trucks under the guise of policemen. Peppino Tucci, their boss, before being arrested accused Sergio Amato of hitting him during an interrogation. Carlotta Santarcangelo, detained daughter of a boss who in the past had tried to kill Fabrizio Nava, asks him to forgive her.

Luciano and Katia, following an anonymous phone call announcing a murder at the zoo, go to check and find a doll with a torn body. The game repeats itself and it turns out to have been worked out by a criminal mastermind as part of a larger and more ruthless plan. Stefano and Sergio instead investigate a case that has to do with the world of pornography.

The police station receives an anonymous tape with video of a man strangling a woman. Sergio and Antonio go to the scene of the crime, an art school, but one of the associates tells them that it is rehearsals for a show. Meanwhile, however, the protagonist of the video has disappeared. Regina Orlando is determined to frame Palizzi, rival chieftain of the Terenzis.

Police officers are investigating a new synthetic drug that is claiming many victims among teenagers. Giancarlo Anelli, Pietro's companion at the police academy, assists the search, but kills the key witness under suspicious circumstances. Fabrizio works on a possible case of circumvention of an incapacitated woman by a beautiful foreigner against an elderly man.

Tania and Sergio prepare for the wedding. Luciano and Laura investigate the assault on a woman and discover a family reduced to poverty due to their obsession with gambling, favored by an unscrupulous criminal who runs a network of clandestine gambling dens.

Lucia Pistrozzi tries to help a friend involved in a bad ride, but is sucked into it in turn. Fabrizio will intervene to resolve the situation. Sergio and Tania get married and Regina also participates in the wedding, accompanied by Guido.

The body of a promising young swimmer, Renato Moretti, is found lying in the pool. Inspector Nava investigates together with two agents and discovers that the boy, convinced by a friend, had started using performance-enhancing substances. Then comes the missing report of Tatiana Crocco, a fourteen-year-old girl, who ran away from home due to the constant quarrels of her adoptive parents.

During the investigation into the Santarcangelo clan, Pietro Guerra is seriously wounded in the head. The team lives moments of great anguish. Meanwhile, Orlando and Amato continue their investigations and manage to find the right lead also thanks to Carlotta Santarcangelo, detained in Poggio Reale and in love with Fabrizio Nava.

Regina Orlando visits the orphanage where she grew up, who lives in a difficult economic situation. Meanwhile, in the garden adjacent to the orphanage, mysterious events take place which Fabrizio and Stefano are investigating. Scary events involving some students occur in a pub: the Sant'Andrea police station sets to work to find an explanation.

Antonella Cantamore, daughter of an old friend of Cafasso's, works in a luxurious brothel. The girl is kidnapped and Cafasso and Regina discuss the methods to be adopted to solve the case. Regina will find the right lead, but she will put Laura and Alfio's lives at risk.

Laura Onorato suffers serious eye injuries during an operation and discovers that she has a permanent lesion. The agents of the police station, while researching Jovine, a criminal expert in fraud, discover drug trafficking. Regina Orlando presents transfer application.

Jerry Tagmaouhi, co-owner of a club together with Mario Maggese, is attacked in the street by three thugs. At first glance it would seem a racist aggression, but Katia's investigations will lead to reveal a different reality. Edoardo and Fabrizio instead investigate the disappearance of a woman following an argument with her spouse.

A journalist working on an investigation into international arms trafficking is involved in the murder of a pensioner. Pietro and Sergio, after an attack by the journalist, decide to act as his escort while they investigate the case. Fabrizio and Stefano, meanwhile, investigate a clandestine car racing ring.

The Sant'Andrea police station is shocked by the suspicion that Stefano, one of the best agents, has become an accomplice to the Camorra: Fabrizio and Pietro work hard to prove his innocence. Meanwhile, Edoardo discovers the violence of Miriam's husband and promises to keep her secret and protect her.

An intricate case that reveals a more disturbing truth than the agents had imagined: that of a young lawyer killed and his alleged killer, found dead of an overdose. The policemen of the police station are also investigating a gang of criminals who use the undergrounds of Naples to rob banks.

A child is found abandoned in a bad street: it turns out to be the son of a collaborator of justice kidnapped by the Camorra. The Sant'Andrea police station also investigates the murder of a university professor who reveals a scandal of exams sold and experiments conducted by the professor. In the meantime, the love story between Miriam and Edoardo continues, behind her husband Luciano.