When paramedics rush in with a stabbing victim, Villanueva is stunned to realize that the patient is his own son, Nick. Now it's up to Sydney and Hooten to save the young man. With Ty's help, Sung attempts to restore a concert violinist's perfect pitch by removing an astrocytoma that is pressing on the musician's brain. And Buck receives a strange request from the donor in a failed kidney transplant.

In the season finale, Hooten and Buck find themselves facing off in court against attorney Mitch Tompkins after a grieving son refuses to comply with his mother's final wishes. Sydney's outrage over the health of a morbidly obese 16-year-old boy further strains her relationship with Lieberman. And a seemingly harmless patient puts one of Chelsea General's own in grave danger.