The first season of Homicide: Life on the Street, an American police procedural drama television series, originally aired in the United States on NBC between January 31 and March 31, 1993. The show was created by Paul Attanasio, with film director Barry Levinson and television writer and producer Tom Fontana serving as executive producers. Adapted from David Simon's 1991 non-fiction book Homicide: A Year on the Killing Streets, the season followed the fictional detectives of Baltimore Police Department homicide unit and the murder cases they investigate. The show was broadcast on Wednesdays at 9 p.m. EST, with the exception of the series premiere, which aired immediately after Super Bowl XXVII.

The season introduced regular cast members Daniel Baldwin, Ned Beatty, Richard Belzer, Andre Braugher, Clark Johnson, Yaphet Kotto, Melissa Leo, Jon Polito and Kyle Secor. Most of the primary characters were based on real-life Baltimore detectives from Simon's book, including Gary D'Addario, Terrence McLarney, Harry Edgerton, Donald Worden and Jay Landsman. Many of the first season story arcs were also adapted from the book, most notably the 1988 Baltimore slaying of 11-year-old Latonya Kim Wallace, which was the basis for the murder case of Adena Watson in Homicide. "Night of the Dead Living", originally written as the third episode, was moved to become the season finale at the insistence of NBC executives, which led to several notable continuity errors.