The fourth season of Homicide: Life on the Street aired in the United States on the NBC television network from October 20, 1995 to May 17, 1996 and contained 22 episodes.

The fourth season marked the debut of two characters: Detective Mike Kellerman, who transfers from Arson to Homicide; and J. H. Brodie, a news cameraman who hires on as the unit's videographer. The season was also the last to feature Captain/Detective Megan Russert as a regular. Drug Kingpin: Luther Mahoney also makes his first appearance. Stuart Gharty also debuts in a guest appearance.

Celebrities appearances include Lily Tomlin, Jeffrey Donovan, Bruce Campbell, Jerry Orbach, Benjamin Bratt, Jill Hennessy, Chris Rock, and Jay Leno.

The DVD box set of season 4 was released for Region 1 on March 30, 2004. The set includes all 22 season 4 episodes on six discs.