The first episode tells the story of the meteor shower that hit Smallville and changed life in the Kansas town forever. Clark Kent meets Lex Luthor for the first time and encounters the first in a long line of humans mutated by the strange green meteor rocks that accompanied him on his journey to Earth.

Clark must deal with Greg, a nerdish bug collector with a crush on Lana who gains the ability of various insects and uses them to lash out at anyone who opposes him.

A jock named Sean gains the ability to absorb heat from everything and everyone around him, and begins preying on people to gain the heat he needs to survive.

An experiment at the Luthor fertilizer plant makes an old friend of the Kents literally shake and jitter, and he seeks vengeance against the Luthors, who hide the secret of his transformation behind "Level Three" at the local plant.

A guy in charge of a rival fertilizer firm to LuthorCorp's talks an EPA investigator into commiting suicide, then arrives in Metropolis. He is intent on buying up the Kent farm and using the land to build a rival company to Lex's. After shaking hands with the man, Jonathan Kent inexplicably agrees to sell. Lex offers to have his lawyers help. Meanwhile, Clark befriends a local recluse. It turns out that the recluse and Lex's rival were both salesmen who were caught in a car accident and exposed to kryptonite. They both gained the same power of "persuasion" on anyone they touched, as the recluse graphically demonstrates to Clark by having Chloe kiss him! Lex's rival finally manages to shake hands with Lex, and convince him to try and gun down Clark. Clark manages to knock out Lex and the recluse takes out his former partner, "convincing" him to shoot himself. The recluse decides to go back into the world, but not before telling Clark that he shouldn't hide from his powers either.

A man from Lex's past stalks him in conjunction with a mysterious death at Club Zero that Lex may have been responsible for. Meanwhile Chloe looks into Clark's past as an adopted child.