The second season of the American dramedy television series Ugly Betty started on September 27, 2007 in the United States and Canada and including a long, mid-season hiatus ran until May 22, 2008. The second part of the season began airing April 24, 2008.

Due to the fan base gained in the UK, Channel 4 bought the UK rights to Season 2 so they could begin airing it only a week later than the USA. Due to the Writer's Strike of 2007, Ugly Betty went on a hiatus in the UK after the airing of episode "Bananas for Betty". Channel 4 announced that Ugly Betty would return towards the end of 2008 and when it returned on 5 September 2008, received 2.93 million viewers, according to overnight figures, which is a strong figure for Channel 4.

The season would be the last season to be produced in Los Angeles before the show confirmed that it will move to New York City to complement the show's setting in the next and last seasons.

ベティが働く一流ファッション誌『モード』の編集部では、リッチなプレイボーイの編集長ダニエル、その兄でゴージャスな美女に性転換したアレクシス、『モード』の乗っ取りを企む悪魔のようなウィルミナなど個性的なキャラクターたちが、様々なバトルを繰り広げていく。最新ＮＹファッションに加え、今シーズンはあのヴィクトリア・ベッカム、リンジー・ローハン、ナオミ・キャンベルなどの超豪華ゲストスターも登場。仕事に恋に全力投球のベティの姿に、あなたもきっと前向きな気持ちになれるはず。エミー賞とゴールデン・グローブ賞に輝いたアメリカ・フェレーラ演じるチャーミングなベティが、オシャレ度・メゲナイ度・愛され度を更にパワーアップ！観る人すべてに元気をくれるスタイリッシュ・コメディ『アグリー・ベティ』のシーズン２。