The second season of Reign begins with Mary and Francis on the throne of a nation burning. France is rocked by the aftereffects of the plague, a disease that creeps inside the castle walls, taking thousands upon thousands of lives across the land, and ravages the stability of a nation. From the ashes, powerful lords will rise, carrying out personal, religious and political vendettas, taking lives, and tearing at Mary and Francis's commitment to each other, and their people. Friendships will be tested, loved ones murdered and betrayed. Meanwhile, a mysterious and deadly threat snatches victims from village streets and castle corridors; leaving evidence of savagery that looks like the work of monsters; mythical creatures who are the subject of nightmares, but who walk among us, doing the Devil's bidding.

Im Zentrum der Historienserie stehen die teils romantischen, teils dramatischen Abenteuer der schottischen Monarchin Mary, Queen of Scots - in Deutschland unter dem Namen Maria Stuart populär. Bereits als Säugling wurde sie 1543 nach dem Tod ihres Vaters zur offiziellen Thronfolgerin, jedoch übernahm ihre Mutter die Regentschaft.

Alla morte di re Enrico, Mary deve affrontare un paese tormentato dalla peste, i tradimenti dei più fedeli servitori e le violenze commesse in nome della religione.