27 years after a virus wipes out most of humanity, scientists send a man back to 2015 to stop the plague from ever happening. Cole's only lead is a virologist, who knows the dangerous source of the outbreak.

A fight for the future ensues when a dangerous band of marauders hunting for Cole and Ramse threatens the mission to save the past.

Cole finds himself in 2017 at the height of the plague. Out of options, Jones faces an impossible choice to replace the Core.

Forces come to a head when Ramse does what it takes to protect his newfound family, leaving Cole to deal with the aftermath.

With Cole dying from the effects of time-travel, Railly must find the one person who can save him.

Cole and Railly attempt a final confrontation with their closest enemies, while Jones faces a new threat to all that she's accomplished.

Cole and Ramse repair their broken friendship while on the run; Railly and Jones navigate an uncertain future in 2043.

Cole and Railly have finally found peace living in the past. When a mysterious woman with apocalyptic visions of the future tells Cole it's not over, he must do the unthinkable to save the world... and the woman he loves.

In the apocalypse of 2163, a desperate Cole searches for Titan. Meanwhile, a captive Railly is faced with an impossible choice as the 12 Monkeys await the arrival of The Witness.

The final battle with the Witness begins.

Travelers come face to face with ghosts from their past when they find themselves maneuvering around their own timelines.

The team infiltrates a Nazi gala to steal an artifact known as 'Die Glocke'. Their operation comes undone when French Resistance interferes and an unexpected guest arrives.

The final battle against the Witness as the fate of time and mankind hangs in the balance. All the pieces finally come together to mark the end of the beginning.

When all hope is lost, Cole must complete his cycle so that his younger self will one day arrive at the end with the answer.