Вторият сезон на сериала продължава пълната с кръв и насилие история на неаполитанския престъпен синдикат Камората, видяна през очите на лоялният и самоуверен Чиро, който е дясната ръка на кръстника на клана Пиетро Савастано.

The era of the Savastano clan, who once undisputedly reigned over Naples, seems to be hopelessly over. What lies ahead now is the largest ever power vacuum in the history of the Camorra. The king, Don Pietro Savastano, abdicated, at least momentarily. All the forces involved will suddenly have the chance to have their say and will no longer have to submit to the orders of such a tyrannical boss as Don Pietro. But the latter, although physically and mentally tried by hard prison regime, does not seem willing to lose his empire. Many are now vying for what once was the Savastano kingdom. With Ciro l immortale in the forefront, who from the very beginning will be secretly plotting, testing new and old allies, to finally make the big leap he has always aimed for. A leap which now more than ever seems to be within his reach. Meanwhile Salvatore Conte is now waiting for an answer from the bosses of the clan once close to the Savastano's.

Don Pietro a été libéré par ses hommes du fourgon de police pendant le transfert. Ciro, après avoir fait une alliance avec Salvatore Conte, met en sécurité Deborah et sa fille Maria Rita en vue de la revanche à venir des Savastano. Sa femme, cependant, nourrit une inquiétude croissante sur le sort de sa jeune fille, au point d'être tentée de trahir le clan et de se rendre à la police.

Pendant ce temps, Genny lutte pour sa survie à l'hôpital.

L'era dei Savastano, che un tempo regnavano incontrastati su Napoli nord, sembra finita e a contendersi il potere ora sono in tanti. Conte, Pietro, Genny e Ciro: tra sangue, affetto e vendetta, chi sarà in grado di stringere l'alleanza più forte o, forse, quella più inaspettata?

Ciro y O'Nano convencen a Conte de formar una alianza antes de que la familia Savastano se reúna de nuevo. Pietro sigue a la fuga.