The Adventures of Shirley Holmes is a Canadian mystery TV series that originally aired from 1997 to 2000. The show was created by Ellis Iddon and Phil Meagher who had produced a successful series of books with Harper Collins, teaming up with Credo and Forefront to develop the TV series. Filmed in Winnipeg, Manitoba, the series follows the life of Shirley Holmes, the great grand-niece of Sherlock Holmes who, with the help of ex-gang member Bo Sawchuk, tackles a variety of mysteries in and around the fictional Canadian city of Redington. On some occasions, she found herself matching wits with archnemesis Molly Hardy.

The show has been broadcast in over 80 countries and has been dubbed in French, Spanish, Italian, Portuguese, German, Norwegian, Polish and Turkish.

Her performance in the show led to actress Meredith Henderson being nominated for a Gemini Award in 1998 and winning one in 1999. The show itself was twice nominated for a Gemini Award in the category "Best Children's or Youth Program or Series" in 1998 and eventually won it in 1999. In the spring of 1998 Susin Nielsen won a Gemini Award in the category "Best Writing in a Children's or Youth Program" for her screenplay of the episode "The Case of the Burning Building". In the same year, Elizabeth Stewart won a WGC Award from the Writers Guild of Canada for her writing of the episode "The Case of the Maestro's Ghost".

Shirley Holmes, 12 Jahre alt, Urgroßnichte des berühmten Detektiven Sherlock Holmes und nichts kann sie stoppen, einen Fall zu lösen. Shirley verfügt über eine ausgeprägte Beobachtungsgabe, ist furchtlos, schlagfertig und kann, wenn es darauf ankommt, ganz schön frech sein. Einen Doktor Watson hat sie zwar nicht als Assistenten dafür aber Bo (Boris) der nach anfänglicher Skepsis gegenüber ihren Methoden bald unentbehrlich wird. Dem Geheimnis ihrer Herkunft kommt Shirley auf die Spur, als sie eines Tages beim Stöbern auf dem Dachboden eine alte Truhe entdeckt. Im Inneren findet sie einen Brief ihres berühmten Urgroßonkels. Den Finder des Briefes hat er sich allerdings ganz anders vorgestellt.