Like every high school sophomore, all Andie wants is to have someone like her, date her, and possibly make out with her. When her brother makes it impossible for her to land a date, Andie's three best friends each come up with their own clever way to try and help get Andie out of the sister zone.

Media Club advisor Mr. Shaw threatens to close the club if the Foursome doesn't produce a new episode of the school’s newscast, “Cup O'Brayer,” by end of day. Their plans are derailed when a trip to the school’s bake-off leaves the Foursome high as kites.

When boy drama leaves the Foursome frustrated, they want to solve it the best way they know how: GIRLS’ NIGHT (plus Dakota)! But when Alec's boys’ night collides with their girls’ night, they have a showdown to determine who gets to stay.

After a condom lesson gone wrong in health class, Andie realizes that she knows nothing about sex, and even if Josh all of the sudden decided he was interested she would be totally unprepared. Dakota and Courtney agree to teach her how to round the “bases.”

Courtney invites everyone to a frat party at SUC, but when they wake up the morning after, Imogen is missing and the Foursome must retrace their steps to find her.