在江湖打滚多年的老千翟冠一(陈展鹏饰)，被师父司徒省(潘志文饰)召唤，与六位同门何正花(林夏薇饰)、伍柏义(陈山聪饰)、丁权(林子善饰)、李亨(徐荣饰)、吴世峰(黄长兴饰)及苏丽芬(赵希洛饰)一起观战，见证司徒省与骏昇娱乐城老板赌王霍骏昇(单立文饰)的一场世纪之战。这一战让冠一上了一课：「无情才是赢家」!

　　赌王之战完结后，「千门七杰」到娱乐城出任不同岗位，为危机四伏的娱乐城找出内奸。

　　冠一与正花因是次任务被逼朝夕相对，二人本是情侣，还发展至差点结婚的地步，可是冠一曾为得赌王冠军出卖正花，自此二人各不相干。

　　七人当中，冠一跟精通魔术的柏义合作多年，甚有默契，情同手足。冠一等人缩窄调查范围，深入调查与骏昇情同手足的助手林磊(黄子雄饰)，及骏昇的情人知己丘月华(陈秀珠饰)。

　　千头万绪，众人赫然发现另一条与骏昇及林磊有关的线索。原来娱乐城当年由骏昇、林磊与蒋天龙(吴岱融饰)建立，天龙是三人中的大哥，但已失踪多年，生死未卜，而骏昇亦是因天龙的失踪才成为娱乐城的主人。

"Yat Gor" Chak Koon-yat, "Win Jeh" Ho Ching-fa, and "Yee Jai" Hugo Ng have followed their master Szeto Sing to learn con tricks and illusions since childhood. Yat and Fa grow fond of each other over the years, but a competition estranges them and they lose contact. In order to flush out the mole, a casino tycoon named Fok Chun-sing colludes with Szeto to induce Yat and Hugo into taking up a secret mission, resulting in their reunion with Fa. With each of them possessing a unique talent, they gradually uncover that the mole might be Fok's right-hand man Lam Lui, confidant Yau Yuet-wah, or one of their rivals.

But nothing is as it seems. To come into terms to why Fok killed his father Chiang Tin-lung twenty years ago, Yat infiltrates the Chun Sing Group, dealing a crushing blow to the crisis-ridden casino. That leads to an enmity between siblings, total severance of the master-disciple relationship, and irreconcilable differences between father and son.

Tư Đồ Tỉnh (do Phan Chí Văn đóng) là một trong những ông vua cờ bạc. Ông thu nhận và đào tạo bảy đệ tử tài giỏi: Trạch Quán Nhất (do Trần Triển Bằng đóng), vua mạt chược Hà Chánh Hoa (do Lâm Hạ Vy đóng), ảo thuật gia Ngũ Bách Nghĩa (do Trần Sơn Thông đóng), cao thủ võ thuật Đinh Quyền, phụ trách lái xe Lý Hanh, chuyên gia thu thập thông tin Ngô Thế Phong và vua móc túi Tô Lệ Phân...