An anime series about a girl who is secretly an idol is quickly thrown out the window in favor of the crazy, disjointed antics of Popuko and Pipimi. Among other skits, Popuko experiences death and rebirth as she experiences many first encounters with Pipimi, and the two girls go to France in an attempt to use gestures to communicate.

Popiko and Pipimi are inadvertently summoned to an unfinished fantasy anime and makes the heroes do impressions, much to the voice actors' consternation. Other skits include a stop-motion musical performance by felt dolls of Popuko and Pipimi, Popuko drawing a deluge of fortune slips, and Popuko being confronted with the harsh reality of time's passage.

Popuko takes part in the Skeleton World Grand Prix, facing many tough opponents. Other skits include a parody of Earth, Wind & Fire's "Let's Groove", Popuko being forced to evict an extraterrestrial being from her house, and Popuko and Pipimi encountering a boss while exploring a dungeon.

Iyo Sakuragi and Hojo become step-siblings after their parents, portrayed by Popuko and Pipimi, get married. Other skits include a cooking show hosted by Popuko and Pipimi, Pipimi literally growing with affection for Popuko, and Popuko doing a poor impression of Mickey Mouse.

Guided by the spirit of Pipimi, Popuko fights against the Elite Four in a shogi tournament. Other skits include Pipimi's fantasies about attractive male characters distracting her from Popuko's venting, Popuko demonstrating an increasingly bizarre variety of regional activities, and Popuko and Pipimi discussing modern slang.

Musician Hellshake Yano is tasked with holding a concert by himself until his band members arrive. Other skits include dealing with haters, Popuko turning into a baby, and Pipimi going fishing.

Yakuza member Pipi decides to take vengeance against her gang when they stray down the wrong path of committing YouTuber crimes. Other skits include Popuko trying to treat an injury, bacon eating some bacon, and the ending theme singers complaining that they're not in the actual anime.

Popuko and Pipimi encounter a young runaway boy while visiting New York City. Other skits include Popuko ordering latte art, Pipimi attempting standup comedy, and the girls trying French cuisine.

While staying at a hot spring inn, hostesses Popuko and Pipimi investigate a murder that has taken place. Other skits include the girls playing soccer, Pipimi cooking some premium meat, and Popuko dealing with incompetent waiters.

A group of college students find the mansion they are staying in to be haunted by Popuko and Pipimi. Other skits include Popuko starting a dance craze, Pipimi becoming giant, and Popuko going up against a shark.

Popuko and Pipimi have a final showdown against the evil organization trying to stop their anime, King Records. Other skits include a scene parodying magical girl anime tropes in which a girl brings a talking pet to school with her and Popuko trying to find her glasses. After the credits, there is a teaser trailer for a second season of Hoshiiro Girldrop.