Season 1 of Naagin premiered on November 1, 2015.

Shivanya a mythical Ichchadhari Naagin (shape-shifting serpent) witnesses the slaying of her parents and vows revenge. Her plan involves enamouring Ritik, the son of her parents' murderers. Little did she expect to fall in love with the innocent Ritik and bring about an unwanted conflict between her love and desire for vengeance.

Season 2 of Naagin premiered on October 8, 2016.

This season sees a continuation of the feud between the Naagin and her nemesis. Her progeny Shivangi falls hopelessly in love with a descendant of her parents' slayers, Rocky. Even though Shivanya tries desperately to isolate Shivangi from her (Shivangi's) true identity; eventually the girl embraces her true nature and tries to protect her life and the treasure of the snake people, the fabled Naagmani.

Season 3 of Naagin premiered on June 2, 2018.

Love and mystery abound in this season, as Ruhi, an Ichchadhari Naagin has waited a century to reunite with her true love, Naagraj Vikrant. After Vikrant is murdered by some hooligans, Ruhi takes on a plethora of forms to avenge his death.

Season 4 of Naagin premiered on December 14, 2019.

Two Ichchadhari Naagins - Brinda and Nayantara's lives are entwined in a saga of revenge and deceit. Brinda seeks justice for her parents' murder, while innocent Nayantara is torn between what's right and her loyalty to her friend, Brinda.

Season 5 of Naagin premiered on August 9, 2020.

This is a story of love and vengeance. Natural foes, the progeny of an eagle and a snake fall in love. But their love is forbidden. They must now continue to either resist or give in to this love. Will their forbidden love stand the test of this world and will what is ordained as unnatural prevail, despite the odds?

Season 6 of Naagin premiered on February 12, 2022.

Naagin in this season returns more powerful and this time she is battling an enemy that is bigger than ever before and avenge her countrymen. She is the Naagin of the new world - a world where a global crisis has emerged, where India is under a biological attack. A global pandemic has affected all countries and battered the world economy with seemingly no cure. The wise and spiritual leaders of the subcontinent foresee the imminent arrival of a catastrophe and they know there is only one who can counter it. They evoke Naagin and plead her to use her mystical powers to help, she agrees but on the condition that she will also seek her own personal vendetta from the people who wronged her.