A triple murder divides a small town in Kentucky. As secrets come tumbling out, residents begin to wonder: How well do we really know our neighbors? Keith Morrison reports.

A family’s search for answers in the 2014 disappearance of 28-year-old Fayetteville, North Carolina construction worker James Chambers. Andrea Canning reports.

A man goes overboard on a romantic sunrise cruise with his wife on Lake Coeur d'Alene in Idaho. Investigators begin to think his death may not have been an accident. Keith Morrison reports.

After a 27-year-old woman is found murdered in her Michigan home, investigators quickly identify a person of interest, but years pass without an arrest. Andrea Canning reports.

Josh Mankiewicz reports the latest developments following an arrest in the Kristin Smart case; Craig Melvin reports on the mysteries surrounding the powerful Murdaugh family of South Carolina.

Investigators desperately search for a killer after Florida teacher Denise Hallowell is found murdered. Dennis Murphy reports.

New evidence, exclusive interviews, and an in-depth look at Lori Vallow and Chad Daybell, the Idaho couple charged in the murders of Lori’s children JJ & Tylee. Keith Morrison reports.

Drew Peterson speaks to Natalie Morales in his first on-camera interview in over a decade about the murder of his ex-wife, Kathleen Savio, and the disappearance of his fourth wife, Stacy.

New details expose how the Gucci empire was undone by jealousy, backstabbing and an act of murder.

Insiders speak out about the sex trafficking case against fashion mogul Peter Nygard.

Keith Morrison reexamines the mysterious death of Las Vegas casino magnate Ted Binion.

A Connecticut mother speaks out about her fight to keep her assailant from walking free.

Investigators search for answers after a 17-year-old is murdered after a Valentine's Day dance.

Insiders close to the case of missing Colorado mother Suzanne Morphew speak out for the first time.

An investigation into the death of a world-renowned snake breeder reveals a sinister betrayal.

A mystery in paradise unfolds when a woman vanishes from a luxury yacht in the U.S. Virgin Islands.

Investigators uncover a puzzling connection between two women who disappeared two decades apart.

A Phoenix family gathering ends with a suspicious death and more than a decade of questions.

New details emerge in an alleged murder-for-hire plot targeting a former NYC cop's husband.

Detectives search for a motive in the fatal stabbing of former Sen. Linda Collins of Arkansas.

New interviews reveal the latest twists and turns in the case of Pam Hupp, charged in the murder of her close friend Betsy Faria; Betsy's daughter, as well as the prosecutor behind the wrongful conviction of Betsy's husband speak out.

California detectives reveal new details about the alleged kidnapping of Sherri Papini.

New Jersey detectives investigate a report that a 5-year-old boy vanished from a carnival.

Detectives search for a motive in the fatal stabbing of Oregon mother Annastasia "Annie" Hester.

Insiders reveal new details on the 2016 murder of a plastic surgeon in Asheville, N.C.

Insiders speak out about the latest developments in the suspicious death of a New York woman.

When 18-year-old Anjelica Hadsell disappears, the investigation uncovers a sinister betrayal.

After an Oregon chef is murdered, investigators uncover a potential clue written years earlier.

Amber Heard speaks out in her first interview since the defamation trial brought by Johnny Depp.

When 19-year-old Anton Black dies while being taken into police custody, the community seeks justice; a yearlong "Dateline" investigation looks at the officer at the center of the case and missed warning signs.