Ten actresses begin their quest to become the next Scream Queen and win a breakout role in SAW VI. In the series premiere, the girls must take on the role of being in a bathtub and going from sexy to scared, when a snake enters the bathtub. (This scene is taken from the movie 'Slither'.)

The girls are evaluated on their first impressions by casting director Kelly Wagner. Two of the girls get a much-needed makeover. For the director's challenge, the girls pose for a movie poster photo shoot.

The eight remaining actresses must learn to jump out of a three-story window. The girls are rewarded with a night on the town, but soon the fun turns ugly.

The remaining girls learn to work with even the worst scripts and co-stars when they play a character with no body based off the 1962 movie The Brain That Wouldn't Die. For the director's challenge, the girls are cast in roles for a horror movie trailer directed by James Gunn. One of the girls makes a fateful decision.

The six remaining actresses must dive into a pool of blood, climb into a morgue drawer, and cover themselves in cockroaches in the hopes of not being eliminated this week.

The remaining girls must act possessed. There is a misunderstanding in John Homa's acting class that leads to a fight between two of the girls. The judges drop a bombshell on the girls during elimination.

The girls have their most difficult acting partner to date: themselves!