杜仲（郭晋安 饰）是京城内的一位名医，因为医好慈禧太后（罗兰 饰）久治不愈的疑难杂症而被破格升职为御医，迁入了紫禁城之内。成为御医之后，杜仲凭借着他聪慧的才智和高超的医术闻名于红墙之内，深得皇上和太后的信任。然而，杜仲却在被囚的光绪身上看到了夺目的帝王之气，并因此而被卷入了残酷的政治斗争之中。

　　杜仲家中有一妻洪百合（贾晓晨 饰），因其不能生育，又纳了茯苓（杨怡 饰）为妾。哪知道茯苓侠肝义胆，竟在洞房花烛之夜和人私奔，杜仲为了成全这段郎情妾意，写下了休书成全他们两人。哪知道数年后，被情人抛弃的茯苓和杜仲重逢并成为了好友，两人合作天衣无缝屡破奇案，时间久了，居然真的生出了情愫

During the late reign of the Qing dynasty skilled physician To Chung is named the new Imperial Palace Physician when he successfully heals Empress Dowager Chee Hei from her illness. To Chung eventually grows close to the Gwong-seoi Emperor who is under house arrest at the Forbidden City and stripped of his powers after angering Dowager Chee Hei due to losing the First Sino-Japanese War and rebelling against her authority. To Chung also heals Gwong-seoi Emperor from his illness and helps the young emperor with his relationship with Consort Tsan. However how great he is as a physician to the imperial family, To Chung cannot heal his crippled wife Hung Bak-hap. Desperate to heal his wife he seeks out the services of bone-setter Fuk Ling. Fuk Ling's treatments help Bak-hap relieve some of her pain. Impress by Fuk Ling, To Chung refers her to the Forbidden City where she becomes Empress Dowager Chee-hei personal bone-setter. To Chung and Fuk Ling's friendship eventually turns romantic but his loyalty to his wife Bak-hap prevents him from further pursuing his romance interest in Fuk Ling. Fuk Ling, however, has ulterior motives for getting close to the imperial family as she has been tasked to kill the Gwong-seoi Emperor.