The owner of a cosmetics company is unveiling a new cream which she claims she's been using. She's been keeping her age a secret and now reveals that she's 60 and owes her appearance to the cream. She's later killed and the formula missing. Her husband is arrested and Perry defends him.
After giving the District Attorney another stinging defeat, Perry plans to take a vacation in China. That is, he was, until Rhoda, his old flame, meets him at a restaurant. It seems that her husband Moxley, who had been allegedly dead for four years, is alive and demanding money as she has married into wealth. The case escalates when the police find the body of Moxley and charge her with the murder.
A young theatre director is accused of killing a more famous Broadway director. Perry takes his case.
Perry Mason defends the husband of a famous rock singer who was found being killed after having had a tremendous discussion with her husband and her manager.
A young woman from Las Vegas wants Perry Mason to defend her father.
An actor rigs a fake shooting on TV with the connivance of his friend, the show's host, but the practical joke goes wrong when the gun turns out to contain a live round.
Perry Mason is invited to the marriage of the daughter of an old friend of his. But after the ceremony the uncle of the bride is dead. Certainly this is a case for Perry Mason.
When his former secretary is accused of a murder, Perry Mason gives up a judgeship to defend her.
Sleazy talk show host Ted Mayne writes a tell-all book, which enrages and embarrasses several very prominent women. One of them, actress Roxanne Shield, loses her composure during an interview and winds up making a televised death threat. Of course, when Ted is murdered, she is arrested. Witnesses claim they saw Roxanne outside his apartment that night and police later find the murder weapon in her car. Renowned defence attorney Perry Mason accepts the challenge of defending her in court.
A very nervous man named Cartwright comes into Perry's office to have the neighbor arrested for his howling dog. He states that the howling is a sign that there is a death in the neighborhood. He also wants a will written giving his estate to the lady living at the neighbors house. It is all very mysterious and by the next day, his will is changed and Cartwright is missing, as is the lady of the house next door. Perry has a will and a retainer and must find out whether he has a client or a beneficiary.
Perry must defend the husband of an old flame from a murder charge.
Ken Malansky, a law student of Perry Mason's, is accused of murdering a fellow student. Perry is reluctant to take on his case as the victim was the son of a close friend.
Perry investigates the murder of a former madam and uncovers a multimillion dollar banking fraud in the process.
The chief suspects in the murder of an author are the numerous colleagues whom he continuously plagiarized.
On the set of a popular daytime soap opera 'Mile High', actress Kris Buckner is being forced off by co-star Mark Stratton. When she says that she'll 'kill him before she leaves the show', she makes herself the prime suspect when Stratton is murdered by someone poisoning him. As an old friend, Perry Mason comes to the help of Kris and agrees to defend her. Meanwhile Ken goes in search of information with the help of fan of the show.
Mason defends a man he had sentenced to prison when he was an appellate-court judge. Now, 18 months after the sentencing, a new witness turns up to prove the man's innocence. Mason steps in to defend the man.
A painter, believed to be dead, returns to make allegations that a gallery owner is selling counterfeits of his work. Later, the artist is murdered.
A priest is murdered and the main suspect is a nun.
Perry is at TV station "KGGY" to be interviewed but thanks to the interference of main anchor-person Brett Huston the interview is pulled. Mostly everybody hates Brett as Brett knows all the station workers secrets. He has also written a memo insulting all of the main station players - Vic St. John - the station manager, Twyla Cooper - the producer, Chuck Gilmore - the sports reporter, Gary Slate - the weatherman, Cassie Woodfield - the reporter and Gillian Pope. Brett is shot dead with Gillian's gun and therefore is arrested for the crime. Gillian calls in Perry, Della and Ken to investigate. As Della and Perry set out to solve the mystery, Ken gets close to Cassie but she is a suspect and when it appears that somebody is trying to kill her, the mystery deepens..
Anthony Caruso, an old friend of Perry Mason, comes to Denver on the request of Dee Morrison. She's married to famed photographer David Morrison, who wants to shoot a photo featuring his former models. The tricky thing is that all of his former models are also his former wives. But Dee knows Anthony can convince them to do it which he does. And David shoots them. Later Dee catches David it what appears to be in an inappropriate situation with his assistant. They have an argument and she leaves. Later David is found dead and she's arrested and Anthony defends her. And he suspects it could have been one of the wives