In the midst of societal conflict in the futuristic city of Metropolis, Kenichi and his uncle Shunsaku Ban set out to uncover the mystery behind the first human-like robot, Tima.

Faye attempts to replace her newly deceased husband, Evan, with an android simulant (SIM). Although SIM Evan appears like human Evan in every way, Faye does not feel the same love for SIM Evan as it does for her. SIM Evan tries to win Faye back while at the same time being on-the-run from a government agent chasing down SIMs who have become “conscious” and could potentially be a threat to humankind.

In the not-too-distant future, androids have come into common usage. However, treating androids on the same level as humans is frowned upon, and there is constant paranoia surrounding the possibility of robots defying humans, their masters. Those who appear too trustworthy of their androids are chided and labeled as "android-holics". Rikuo Sakisaka, who has taken robots for granted for his entire life, one day discovers that Sammy, his home android, has been acting independently and coming and going on her own. He finds a strange phrase recorded in her activity log, "Are you enjoying the time of EVE?". He, along with his friend Masakazu Masaki, traces Sammy's movements and finds an unusual café. Nagi, the barista, informs them that the café's main rule is to not discriminate between humans and androids. While Rikuo tries to reveal Sammy's intentions, he begins to question the legitimacy of the fear that drives humans to regard androids as nothing more than mere tools.

In a not-so-distant future, couples can share pregnancy on a more equal footing via detachable artificial wombs. While botanist Alvy has doubts about this new way of birthing babies, his love for Rachel prompts him to take a leap of faith.